Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-

Base Information

Chemical Name:Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-
CAS No.:137941-92-5
Molecular Formula:C27H29N3O4S
Molecular Weight:491.6019
Hs Code.:
ChEMBL ID:CHEMBL326216
Nikkaji Number:J449.449K

Synonyms:Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-;CHEMBL326216;SCHEMBL9737861;AKOS040754400;PD159774

Suppliers and Price of Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-

Chemical Property:

Vapor Pressure:3.57E-17mmHg at 25°C
Boiling Point:657.7°Cat760mmHg
Flash Point:351.6°C
Density:1.28g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:415.15657746
Heavy Atom Count:29
Complexity:589

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CC1=NC2=CC=CC=C2C=C1)CC(COC3=CC=C(C=C3)NS(=O)(=O)C)O
Isomeric SMILES:CN(CC1=NC2=CC=CC=C2C=C1)C[C@@H](COC3=CC=C(C=C3)NS(=O)(=O)C)O

Technology Process of Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]-

There total 6 articles about Methanesulfonamide, N-[4-[(2S)-2-hydroxy-3-[methyl(2-quinolinylmethyl)amino]propoxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 137898-71-6
(S)-1-(4-Amino-phenoxy)-3-(methyl-quinolin-2-ylmethyl-amino)-propan-2-ol

: 124-63-0
methanesulfonyl chloride

: 137941-92-5
(-)-(S)-N-<4-<2-hydroxy-3-propoxy>phenyl>methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00115a010

Reference yield:

: 137941-95-8
(S)-1-[methyl(2-quinolinylmethyl)amino]-3-(4-nitrophenoxy)-2-propanol

: 124-63-0
methanesulfonyl chloride

: 137941-92-5
(-)-(S)-N-<4-<2-hydroxy-3-propoxy>phenyl>methanesulfonamide

Guidance literature:: With pyridine; palladium-carbon; In H₂; ethanol; dichloromethane;

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 137941-92-5
(-)-(S)-N-<4-<2-hydroxy-3-propoxy>phenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂O / 3.33 h / 10 - 20 °C

2: 63 percent / acetonitrile / Heating

3: 95 percent / H₂ / 5percent Pd/C / ethanol / 3 h / 2585.7 Torr

4: 72 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00115a010