N1-(4-NITROPHENYL)-2-CHLOROACETAMIDE

Base Information

• Chemical Name: N1-(4-NITROPHENYL)-2-CHLOROACETAMIDE
• CAS No.: 17329-87-2
• Molecular Formula: C8H7ClN2O3
• Molecular Weight: 214.608
• Hs Code.: 2924299090
• Mol file: 17329-87-2.mol

Synonyms:Acetanilide,2-chloro-4'-nitro- (6CI,7CI,8CI);2-Chloro-4'-nitroacetanilide;2-Chloro-N-(4-nitrophenyl)acetamide;2-Chloro-N-(p-nitrophenyl)acetamide;4-Nitro-a-chloroacetanilide;N-(4-Nitrophenyl)-2-chloroacetamide;N-(4-Nitrophenyl)-2-chloroethanamide;N-(4-Nitrophenyl)chloroacetamide;N-(Chloroacetyl)-p-nitroaniline;N-Chloroacetyl-4-nitroaniline;N-Chloroacetyl-4-nitrobenzeneamine;NSC 160922;a-Chloro-N-(4-nitrophenyl)acetamide;a-Chloro-p-nitroacetanilide;

Chemical Property of N1-(4-NITROPHENYL)-2-CHLOROACETAMIDE

Chemical Property:

• Vapor Pressure: 6.39E-08mmHg at 25°C
• Melting Point: 185 - 186oC
• Refractive Index: 1.63
• Boiling Point: 439.416 °C at 760 mmHg
• Flash Point: 219.551 °C
• PSA: 74.92000
• Density: 1.473 g/cm³
• LogP: 2.36830

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(4-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-(4-NITROPHENYL)-2-CHLOROACETAMIDE

There total 12 articles about N1-(4-NITROPHENYL)-2-CHLOROACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-nitro-aniline (100-01-6,104810-17-5) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(4-nitro-phenyl)-acetamide (17329-87-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b00730

Reference yield: 93.0%

4-nitro-aniline (100-01-6,104810-17-5) → 2-chloro-N-(4-nitro-phenyl)-acetamide (17329-87-2)

Guidance literature:

With chloroacetyl chloride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.tet.2016.11.076

Reference yield: 89.3%

4-nitro-aniline (100-01-6,104810-17-5) + Chloroacetic anhydride (541-88-8) → 2-chloro-N-(4-nitro-phenyl)-acetamide (17329-87-2)

Guidance literature:

4-nitro-aniline; With sodium carbonate; In water; toluene; for 1h; Large scale;

Chloroacetic anhydride; In water; toluene; at 20 ℃; for 4h; Large scale;

upstream raw materials:

4-nitro-aniline

chloroacetic acid

chloroacetyl chloride

N-chloroacetyl-aniline

Downstream raw materials:

N-(4-nitrophenyl)-2-(1H-pyrazol-1-yl)acetamide

2-{2-[(2,6-dichlorophenyl)amino]phenylmethyl}-3-{4-[(4-nitrophenyl)amino]oxazol-2-yl}-6-bromoquinazolin-4(3H)-on

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(N-(4-nitrophenyl)acetamide)

2-([1,4'-bipiperidin]-1'-yl)-N-(4-nitrophenyl)acetamide

Refernces

• 1、 Hosseinpoor, Hona,Moghadam Farid, Sara,Iraji, Aida,Askari, Sadegh,Edraki, Najmeh,Hosseini, Samanesadat,Jamshidzadeh, Akram,Larijani, Bagher,Attarroshan, Mahshid,Pirhadi, Somayeh,Mahdavi, Mohammad,Khoshneviszadeh, Mehdi. "Anti-melanogenesis and anti-tyrosinase properties of aryl-substituted acetamides of phenoxy methyl triazole conjugated with thiosemicarbazide: Design, synthesis and biological evaluations". . . Retrieved 2021.
• 2、 Pantalon Juraj, Natalija,Mileti?, Goran I.,Peri?, Berislav,Popovi?, Zora,Smre?ki, Neven,Vianello, Robert,Kirin, Sre?ko I.. "Stereochemistry of Hexacoordinated Zn(II), Cu(II), Ni(II), and Co(II) Complexes with Iminodiacetamide Ligands". . p. 16445 - 16457. Retrieved 2019.
• 3、 Gupta, Rajesh Kumar,Jain, Neha,Kumar, Amit,Sarkar, Anjana,Sharma, Deeksha,Sharma, Saurabh,Sinha, Niharika,Tyagi, Jaya Sivaswami. "Novel benzoic thiazolidin-4-one derivatives targeting DevR/DosR dormancy regulator of Mycobacterium tuberculosis". . . Retrieved 2022/01/14.
• 4、 Bozdeveci, Arif,Krishna, Vagolu Siva,Sriram, Dharmarajan,Alpay Karao?lu, ?engül,Kü?ükgüzel, ?lkay,Kulaba?, Necla,Türe, Asl?. "Novel fluoroquinolones containing 2-arylamino-2-oxoethyl fragment: Design, synthesis, evaluation of antibacterial and antituberculosis activities and molecular modeling studies". . . Retrieved 2022/01/11.