6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester

Base Information

Chemical Name:6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester
CAS No.:38835-17-5
Molecular Formula:C17H20O5
Molecular Weight:304.343
Hs Code.:
DSSTox Substance ID:DTXSID80959623
Nikkaji Number:J588.540J

Synonyms:2,3-Dihydroxyethyl naproxenate;38835-17-5;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester;2,3-dihydroxypropyl 2-(6-methoxynaphthalen-2-yl)propanoate;2-NAPHTHALENEACETIC ACID, 6-METHOXY-alpha-METHYL-, 2,3-DIHYDROXYPROPYL ESTER;DTXSID80959623;LS-94339;2-(6-Methoxy-2-naphthyl)propanoic acid 2,3-dihydroxypropyl ester

Suppliers and Price of 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester

Chemical Property:

Vapor Pressure:8.06E-11mmHg at 25°C
Boiling Point:500.1°C at 760 mmHg
PKA:13.12±0.20(Predicted)
Flash Point:182.2°C
PSA：75.99000
Density:1.237g/cm³
LogP:1.84830
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:304.13107373
Heavy Atom Count:22
Complexity:359

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCC(CO)O

Technology Process of 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester

There total 2 articles about 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 2,3-dihydroxypropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 38835-19-7
2-(6-methoxy-naphthalen-2-yl)-propionic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

: 38835-17-5
(D,L)-1-naproxenoylglycerol

Guidance literature:: With acetic acid; In acetone; at 20 - 70 ℃;

Reference yield:

: 23981-80-8
naproxen

: 38835-17-5
(D,L)-1-naproxenoylglycerol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / CH₂Cl₂ / 0.25 h

1.2: 72 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / Heating

2.1: aq. HCl / 65 °C / pH 2

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; 1.1: Addition / 1.2: Substitution / 2.1: Hydrolysis;

Reference yield:

: 38835-17-5
(D,L)-1-naproxenoylglycerol

: 23981-80-8
naproxen

Guidance literature:: With Theorell-Stenhagen buffer system; In water; at 60 ℃; for 7h; pH=9; Further Variations:; pH-values; Solvents; Reagents; Kinetics;