Welcome to LookChem.com Sign In|Join Free

CAS

  • or

23981-80-8

Post Buying Request

23981-80-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

23981-80-8 Usage

Description

(+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID is an organic compound with the chemical formula C13H12O3. It is a white solid and is known for its anti-inflammatory, analgesic, and antipyretic properties. (+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and is characterized by its naphthalene-based structure with a methoxy group and a propionic acid functional group.

Uses

Used in Pharmaceutical Industry:
(+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID is used as an active pharmaceutical ingredient (API) for the development of non-steroidal anti-inflammatory drugs (NSAIDs). Its application is based on its ability to reduce inflammation, alleviate pain, and lower fever, making it a valuable component in the treatment of various conditions such as arthritis, headaches, and other inflammatory disorders.
Used in Research and Development:
In the field of research and development, (+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID serves as a key compound for studying the structure-activity relationships of NSAIDs. Its unique chemical structure allows scientists to investigate the effects of modifications on its anti-inflammatory, analgesic, and antipyretic properties, potentially leading to the discovery of more effective and safer NSAIDs.
Used in Chemical Synthesis:
(+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID can also be used as a starting material or intermediate in the synthesis of other related compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science. Its versatile chemical structure makes it a valuable building block for the development of novel molecules with improved properties and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 23981-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,8 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23981-80:
(7*2)+(6*3)+(5*9)+(4*8)+(3*1)+(2*8)+(1*0)=128
128 % 10 = 8
So 23981-80-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

23981-80-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M1220)  (±)-2-(6-Methoxy-2-naphthyl)propionic Acid  >98.0%(GC)(T)

  • 23981-80-8

  • 5g

  • 250.00CNY

  • Detail
  • TCI America

  • (M1220)  (±)-2-(6-Methoxy-2-naphthyl)propionic Acid  >98.0%(GC)(T)

  • 23981-80-8

  • 25g

  • 890.00CNY

  • Detail
  • Sigma-Aldrich

  • (Y0000399)  Naproxen (racemic)  

  • 23981-80-8

  • Y0000399

  • 1,880.19CNY

  • Detail

23981-80-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(6-methoxynaphthalen-2-yl)propanoic acid

1.2 Other means of identification

Product number -
Other names Naxyn

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23981-80-8 SDS

23981-80-8Relevant articles and documents

Racemization and hydrolysis of (S)-naproxen 2,2,2-trifluoroethyl ester in non-polar solvents by strong neutral bases: Implication for ion-pair kinetic basicity and hydrolysis

Lin, Man-Yuan,Lay, Eddy,Wen, Wen-Yen,Dewi, Hamza,Cheng, Yu-Chi,Tsai, Shau-Wei

, p. 387 - 392 (2004)

By using strong neutral bases as catalyst, a detailed investigation of the racemization of (S)-naproxen 2,2,2-trifluoroethyl ester was conducted in the non-polar solvents isooctane, cyclohexane and n-hexane. The second-order interconversion constant kint* as representing the ion-pair kinetic basicity in isooctane was first estimated and correlated with the equilibrium ion-pair basicity pKip in tetrahydrofuran, giving slopes of 0.768 and 0.689 for non-phosphazene and phosphazene bases, respectively, in the Bronsted correlations. The result was further compared with that for (S)-naproxen 2,2,2-trifluoroethyl thioester, showing about a 1-2 orders of magnitude enhancement of kint* for the corresponding thio-containing analogue. A smaller influence of non-polar solvents (i.e. isooctane, n-hexane and cyclohexane) on kint* was found. Kinetic analysis of the racemization and hydrolysis of (S)-naproxen 2,2,2-trifluoroethyl ester in isooctane and n-hexane containing 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene and water suggests nucleophilic hydrolysis by the base, where the breakdown of tetrahedral intermediates I R1 and IS1 is the rate-limiting step and the hydrolysis constant khy is in proportion to the product of base and ion-pair concentrations. Copyright 2004 John Wiley & Sons, Ltd.

Simple synthetic approach to arylacetic NSAIAs via TosMIC procedure

Di Santo,Costi,Massa,Artico

, p. 787 - 793 (1995)

Preparation of 1-methylpyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl) pyrrole-2-acetonitrile and 2-(6-methoxy-2-naphthyl)propionitrile by treatment of 1-methylpyrrole-2-carboxaldehyde, 1-methyl-5-(4-methylbenzoyl)pyrrole-2-carboxaldehyde and, respectively, 6-methoxy-2-acetylnaphthalene with tosylmethylisocyanide (TosMIC) is described. This one-step synthetic procedure is very useful to obtain the nitrile precursors of tolmetin and naproxen, two clinically important non-steroidal antiinflammatory agents (NSAIAs).

Naproxen impurity and preparation method thereof

-

Paragraph 0033; 0039, (2021/02/06)

The invention provides a naproxen impurity R, and the structural formula of the naproxen impurity R is shown in the specification. The invention also provides a preparation method of the naproxen impurity R. The preparation method comprises the following steps of: demethylating naproxen racemate in an acidic medium, and further reacting the demethylated naproxen racemate with 3-bromo-2, 2-dimethyl-1-propanol in the presence of an acid-binding agent to obtain the naproxen impurity R. The naproxen impurity R disclosed by the invention is suitable for being used as an impurity reference substancefor researching the synthesis quality of naproxen and intermediates thereof.

Preparation of One-Pot Immobilized Lipase with Fe3O4 Nanoparticles Into Metal-Organic Framework For Enantioselective Hydrolysis of (R,S)-Naproxen Methyl Ester

Ozyilmaz, Elif,Ascioglu, Sebahat,Yilmaz, Mustafa

, p. 3687 - 3694 (2021/06/25)

Immobilization of enzyme to magnetic metal-organic frameworks (MOF) can preserve biological functionality in harsh environments to increase enzymes activity, stability, and improve reusability. The magnetic Fe3O4 nanoparticles were treated with calix[4]arene tetracarboxylic acid (Calix) and Candida rugosa lipase (CRL), and then encapsulated into the zeolitic imidazole framework-8 (Fe3O4@Calix-ZIF-8@CRL). The lipase activity data of Fe3O4@Calix-ZIF-8@CRL was 2.88 times higher than that of the Fe3O4@ZIF-8@CRL (without Calix). The catalytic properties of immobilized lipases were studied on the enantioselective hydrolysis of R/S-naproxen methyl ester. It was also observed that Fe3O4@Calix-ZIF-8@CRL has excellent enantioselectivity (E=371) compared to Fe3O4@ZIF-8@CRL (E=131). Furthermore, Fe3O4@Calix-ZIF-8@CRL was seen to still retain 30 % of the conversion rate after the fifth reuse. This work may also be useful for the pharmaceutical industry due to the increased reusability and stability of enzymes, the enantiomeric selectivity exhibited by MOF-enzyme biocomposites, and the significant differences in the biological activities of the enantiomers.

Method for synthesizing aryl propionic acid by metal-free catalysis of carbon dioxide carboxylation

-

Paragraph 0065-0067, (2021/02/10)

The invention relates to the field of carbon dioxide immobilization and conversion, and particularly discloses a method for synthesizing aryl propionic acid by metal-free catalysis of carbon dioxide carboxylation. The method comprises the following steps: stirring a mixed solution of a diselenide catalyst and a styrene compound in a carbon dioxide atmosphere, adding hydrogen peroxide, and stirringto react, thereby obtaining the aryl propionic acid. Styrene is directly used as a raw material, diselenide is used as a catalyst to realize a carboxylation reaction of olefin and carbon dioxide, andcompared with metal catalyst residues or halogen-containing byproducts in a traditional synthesis method, the byproducts in the method only contain water, and small molecular diselenide is used as the catalyst to replace the traditional metal catalyst, and metal residuals are avoided.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 23981-80-8