2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester

Base Information

Chemical Name:2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester
CAS No.:86728-40-7
Molecular Formula:C10H12O3S
Molecular Weight:212.26500
Hs Code.:
Mol file:86728-40-7.mol

Synonyms:4-[2]thienyl-acetoacetic acid ethyl ester;3-Oxo-4-thiophen-2-yl-butyric acid ethyl ester;4-[2]Thienyl-acetessigsaeure-aethylester;ethyl α-(thiophen-2-yl)acetoacetate;ethyl 2-thiopheneacetoacetate;2-(3-carbethoxy-2-oxopropyl)thiophene;

Suppliers and Price of 2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 3-oxo-4-(thiophene-2-yl)butanoate 97%
1g
$ 623.00

Atlantic Research Chemicals
Ethyl3-Oxo-4-(thiophene-2-yl)butanoate 95%
1gm:
$ 275.70

Total 8 raw suppliers

Chemical Property of 2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester

Chemical Property:

Boiling Point:70 - 75 °C (0.1 mmHg)
PSA：71.61000
LogP:1.81290

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 3-oxo-4-(thiophene-2-yl)butanoate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester

There total 5 articles about 2-Thiophenebutanoic acid, .beta.-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1003-09-4
2-bromothiophene

: 89186-81-2
1-ethoxy-1,3-bis[(trimethylsilyl)oxy]buta-1,3-diene

: 86728-40-7
ethyl 3-oxo-4-(thiophen-2-yl)butanoate

Guidance literature:: With tri-tert-butyl phosphine; tributyltin fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 65 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.5b02952

Reference yield: 68.0%

: 57382-97-5
ethyl thiophen-2-ylacetate

: 42201-84-3
1-ethoxy-1-(tert-butyldimethylsilyloxy)ethene

: 86728-40-7
ethyl 3-oxo-4-(thiophen-2-yl)butanoate

Guidance literature:: With (tert-Butyldimethylsilyl)bistriflimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/d1ob01785c

Reference yield:

: 141-97-9
ethyl acetoacetate

: 86728-40-7
ethyl 3-oxo-4-(thiophen-2-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 24 h / 20 °C / Inert atmosphere

1.2: 3.25 h / -78 - 20 °C / Inert atmosphere

2.1: tributyltin fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran / 65 °C / Inert atmosphere

With tri-tert-butyl phosphine; tributyltin fluoride; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene;
DOI:10.1021/acs.orglett.5b02952