Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-

Base Information

Chemical Name:Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-
CAS No.:86778-95-2
Molecular Formula:C28H38N4O3
Molecular Weight:478.635
Hs Code.:
ChEMBL ID:CHEMBL1195553
DSSTox Substance ID:DTXSID001136383

Synonyms:CHEMBL1195553;DTXSID001136383;Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-;86778-95-2

Suppliers and Price of Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:478.29439109
Heavy Atom Count:35
Complexity:688

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC=CC=C1)(C(=O)NCCCN)NC(=O)C2CCCN2C(=O)CCCC3=CC=CC=C3
Isomeric SMILES:CC(CC1=CC=CC=C1)(C(=O)NCCCN)NC(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3

Technology Process of Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl-

There total 7 articles about Phenylalaninamide, 1-(1-oxo-4-phenylbutyl)-L-prolyl-N-(3-aminopropyl)-alpha-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86778-94-1
N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide

: 86778-95-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-aminopropylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 3102.9 Torr;
DOI:10.1021/jm00369a017

Reference yield:

: 18496-54-3
phenylbutyric acid chloride

: 86778-95-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-aminopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / pyridine / CH₂Cl₂ / 3 h / 25 °C

2: 79 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: 85 percent / HOBt, NEM, DCC / tetrahydrofuran / pH 7.0-7.5

4: 89 percent / 2.5 N NaOH / methanol / 25 °C

5: 27 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

6: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

With pyridine; N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00369a017

Reference yield:

: 86778-86-1
N-(4-phenylbutanoyl)-L-proline

: 86778-95-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-aminopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / HOBt, NEM, DCC / tetrahydrofuran / pH 7.0-7.5

2: 89 percent / 2.5 N NaOH / methanol / 25 °C

3: 27 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

4: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017