N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide

Base Information

Chemical Name:N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide
CAS No.:86785-37-7
Molecular Formula:C13H11F3N2O2S
Molecular Weight:316.304
Hs Code.:
DSSTox Substance ID:DTXSID50522207
Wikidata:Q82387278

Synonyms:86785-37-7;N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide;DTXSID50522207

Suppliers and Price of N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:316.04933326
Heavy Atom Count:21
Complexity:441

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)N)C(F)(F)F

Technology Process of N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide

There total 4 articles about N-[4-Amino-2-(trifluoromethyl)phenyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 86785-34-4
N-(2-trifluoromethyl-4-nitrophenyl)benzenesulfonamide

: 86785-37-7
2'-(trifluoromethyl)-4'-aminobenzenesulfonanilide

Guidance literature:: With sodium dithionite; In methanol; ammonium hydroxide; 1.) 30 min, 2.) refrigerator, 1 h;
DOI:10.1021/jo00167a002

Reference yield:

: 86802-68-8
N-(2-(trifluoromethyl)phenyl)benzenesulfonamide

: 86785-37-7
2'-(trifluoromethyl)-4'-aminobenzenesulfonanilide

Guidance literature:: Multi-step reaction with 2 steps

1: fuming nitric acid, aq. acetic acid / 24 h / steam bath

2: 60 percent / sodium dithionite / methanol; aq. NH₃ / 1.) 30 min, 2.) refrigerator, 1 h

With sodium dithionite; nitric acid; acetic acid; In methanol; ammonium hydroxide;
DOI:10.1021/jo00167a002

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 86785-37-7
2'-(trifluoromethyl)-4'-aminobenzenesulfonanilide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / pyridine / 8 h / 85 °C

2: fuming nitric acid, aq. acetic acid / 24 h / steam bath

3: 60 percent / sodium dithionite / methanol; aq. NH₃ / 1.) 30 min, 2.) refrigerator, 1 h

With pyridine; sodium dithionite; nitric acid; acetic acid; In methanol; ammonium hydroxide;
DOI:10.1021/jo00167a002