1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
CAS No.:86872-09-5
Molecular Formula:C30H30N2O7
Molecular Weight:530.577
Hs Code.:
DSSTox Substance ID:DTXSID70440939
Nikkaji Number:J843.607J
Wikidata:Q82257448

Synonyms:CTK3C6308;86872-09-5;DTXSID70440939;5'-O-(4-Methoxytrityl)-5-methyluridine

Suppliers and Price of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:530.20530130
Heavy Atom Count:39
Complexity:872

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(C=C5)OC)O)O
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(C=C5)OC)O)O

Technology Process of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione

There total 3 articles about 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 14470-28-1
mono-4-methoxytrityl chloride

: 1463-10-1,642082-80-2
5-Methyluridine

: 86872-09-5
1-(5'-O-(monomethoxytrityl)-β-D-ribofuranosyl)thymine

Guidance literature:: With pyridine; for 16h;
DOI:10.1248/cpb.31.513

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: (3R,45,5R)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2,3,4-triol

: 86872-09-5
1-(5'-O-(monomethoxytrityl)-β-D-ribofuranosyl)thymine

Guidance literature:: thymin; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

(3R,45,5R)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2,3,4-triol; With tributylphosphine; di-isopropyl azodicarboxylate; In acetonitrile; at 0 - 20 ℃; for 12h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.5b02332