Chemical Property of 5-Methyluridine
Chemical Property:
- Appearance/Colour:white powder
- Melting Point:183-184 °C(lit.)
- Refractive Index:1.618
- PKA:9.55±0.10(Predicted)
- PSA：124.78000
- Density:1.576 g/cm3
- LogP:-2.54350
- Storage Temp.:2-8°C
- Solubility.:Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated)
- XLogP3:-1.6
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:258.08518617
- Heavy Atom Count:18
- Complexity:409
- Purity/Quality:
-
99% *data from raw suppliers
5-Methyluridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+
- Statements:
26/27/28
- Safety Statements:
24/25
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
- Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
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Description
5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.
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Uses
A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.
