N-(Cyclohexylmethylene)-2,6-diisopropylaniline

Base Information

• Chemical Name: N-(Cyclohexylmethylene)-2,6-diisopropylaniline
• CAS No.: 869085-71-2
• Molecular Formula: C19H29N
• Molecular Weight: 271.446
• DSSTox Substance ID: DTXSID40585301
• Nikkaji Number: J2.463.269E
• Mol file: 869085-71-2.mol

Synonyms:N-(Cyclohexylmethylene)-2,6-diisopropylaniline;869085-71-2;SCHEMBL18109204;DTXSID40585301;(E)-1-Cyclohexyl-N-[2,6-di(propan-2-yl)phenyl]methanimine

Chemical Property of N-(Cyclohexylmethylene)-2,6-diisopropylaniline

Chemical Property:

• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 271.229999929
• Heavy Atom Count: 20
• Complexity: 283

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)N=CC2CCCCC2

Technology Process of N-(Cyclohexylmethylene)-2,6-diisopropylaniline

There total 1 articles about N-(Cyclohexylmethylene)-2,6-diisopropylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) + cyclohexanecarbaldehyde (2043-61-0) → N-(cyclohexylmethylidene)-2,6-diisopropylaniline (869085-71-2)

Guidance literature:

DOI:10.1002/anie.200501841

Reference yield: 86.0%

N-(cyclohexylmethylidene)-2,6-diisopropylaniline (869085-71-2) + 2,2-Dimethylmalonyl chloride (5659-93-8) → 1-chloro-2-(2,6-diisopropylphenyl)-4,4-dimethyl-2-azaspiro-[5.5]undecane-3,5-dione

Guidance literature:

N-(cyclohexylmethylidene)-2,6-diisopropylaniline; With n-butyllithium; In diethyl ether; hexane; at -0.16 ℃; for 2h; Schlenk technique;

2,2-Dimethylmalonyl chloride; In diethyl ether; dichloromethane; at -78.16 ℃; for 2h;

DOI:10.1107/S2053229621006173

Reference yield: 48.0%

2-methyl-1,2-epoxypropane (558-30-5) + N-(cyclohexylmethylidene)-2,6-diisopropylaniline (869085-71-2) + trifluoromethylsulfonic anhydride (358-23-6) → 2-(2,6-diisopropyl-phenyl)-3,3-dimethyl-2-azonia-spiro[4.5]dec-1-ene; trifluoro-methanesulfonate

Guidance literature:

N-(cyclohexylmethylidene)-2,6-diisopropylaniline; With lithium diisopropyl amide; In diethyl ether; at 0 - 20 ℃; for 2h;

2-methyl-1,2-epoxypropane; In diethyl ether; at 20 ℃; for 12h;

trifluoromethylsulfonic anhydride; In diethyl ether; at -78 - 20 ℃;

DOI:10.1002/anie.200501841

upstream raw materials:

2,6-diisopropylbenzenamine

cyclohexanecarbaldehyde

Downstream raw materials:

C₂₄H₃₈N⁽¹⁺⁾*CF₃O₃S^(1-)

C₂₃H₃₅N