2-choro-4-hydroxy-3-pyridinecarbonitrile

Base Information

• Chemical Name: 2-choro-4-hydroxy-3-pyridinecarbonitrile
• CAS No.: 869802-74-4
• Molecular Formula: C₆H₃ClN₂O
• Molecular Weight: 154.556
• Mol file: 869802-74-4.mol

Synonyms:

Chemical Property of 2-choro-4-hydroxy-3-pyridinecarbonitrile

Chemical Property:

• Boiling Point: 485.9±45.0 °C(Predicted)
• PKA: 4.68±0.10(Predicted)
• PSA: 56.91000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 1.31228

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-hydroxynicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-choro-4-hydroxy-3-pyridinecarbonitrile

There total 5 articles about 2-choro-4-hydroxy-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-chloro-3-cyano-4-methoxypyridine (98645-43-3) → 2-chloro-3-cyano-4-hydroxypyridine (869802-74-4,727737-49-7)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃;

DOI:10.1016/j.bmcl.2009.08.054

Reference yield: 39.0%

2-chloro-3-cyano-4-methoxypyridine (98645-43-3) → 2-chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile (869802-74-4,727737-49-7)

Guidance literature:

With hydrogenchloride; water; acetic acid; for 2h; Heating / reflux;

Reference yield:

2-chloro-3-cyano-4-methoxypyridine (98645-43-3) → 2-bromo-3-cyano-4-hydroxypyridine (635731-97-4,98645-46-6) + 2-chloro-3-cyano-4-hydroxypyridine (869802-74-4,727737-49-7)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; for 2h;

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

(1-ethoxyethylidene)malononitrile

2-chloro-3-cyano-4-methoxypyridine

2-Chlor-4-ethoxypyridin-3-carbonitril

Downstream raw materials:

2-bromo-4-methoxypyridine-3-carbonitrile

2-Chlor-4-ethoxypyridin-3-carbonitril

2-Brom-4-ethoxypyridin-3-carbonitril

2,4-dichloro-3-cyanopyridine

Refernces

• 1、 -. "THIENOPYRIDINE DERIVATIVES". Page/Page column 142-143. . Retrieved 2010/11/26.
• 2、 Zheng, Guo Zhu,Bhatia, Pramila,Daanen, Jerome,Kolasa, Teodozyj,Patel, Meena,Latshaw, Steven,El Kouhen, Odile F.,Chang, Renjie,Uchic, Marie E.,Miller, Loan,Nakane, Masaki,Lehto, Sonya G.,Honore, Marie P.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.. "Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists". . p. 7374 - 7388. Retrieved 2007/10/03.