98645-43-3

Basic information

• Product Name: 2-CHLORO-4-METHOXYNICOTINONITRILE
• Synonyms: 2-CHLORO-4-METHOXYNICOTINONITRILE;AURORA KA-6299;2-chloro-4-Methoxypyridine-3-carbonitrile;2-Chloro-4-Methoxy-nicotinonitrile 2-chloro-3cyano-4Methoxypyridine;2-Chloro-3-cyano-4-methoxypyridine, 2-Chloro-4-methoxypyridine-3-carbonitrile
• CAS NO: 98645-43-3
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.58
• EINECS: -0
• Product Categories: blocks;Carboxes;Pyridines
• Mol File: 98645-43-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 175-176 °C(Solv: methanol (67-56-1))
• Boiling Point: 318.3 °C at 760 mmHg
• Flash Point: 146.3 °C
• Appearance: /
• Density: 1.33 g/cm³
• Vapor Pressure: 0.000365mmHg at 25°C
• Refractive Index: 1.549
• PKA: -0.06±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-CHLORO-4-METHOXYNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHOXYNICOTINONITRILE(98645-43-3)
• EPA Substance Registry System: 2-CHLORO-4-METHOXYNICOTINONITRILE(98645-43-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45
• RIDADR: UN2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 98645-43-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-4-METHOXYNICOTINONITRILE is a chemical compound that belongs to the class of organic compounds known as pyridine carboxylic acids and derivatives. It is a yellow solid with the molecular formula C7H5ClN2O and a molecular weight of 164.58 g/mol. 2-CHLORO-4-METHOXYNICOTINONITRILE is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a key building block in the production of various drugs and agrochemicals. 2-CHLORO-4-METHOXYNICOTINONITRILE is also used in research and development as a chemical reagent. However, it should be handled with care as it is toxic if ingested or inhaled and can cause skin and eye irritation.

InChI:InChI=1/C7H5ClN2O/c1-11-6-2-3-10-7(8)5(6)4-9/h2-3H,1H3

Upstream product

• 67-56-1 methanol 
• 180995-12-4 2,4-dichloro-3-cyanopyridine 
• 869802-74-4 2-chloro-3-cyano-4-hydroxypyridine 
• 21642-98-8 2-hydroxy-4-methoxypyridine-3-carbonitrile 
• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 95689-38-6 1,1-dicyano-4-(N,N-dimethylamino)-2-methoxy-1,3-butadiene 

Downstream Products

• 74133-20-3 4-methoxypyridine-3-carbonitrile 
• 339016-67-0 4-methoxy-2-phenoxynicotinonitrile 
• 635731-97-4 2-bromo-3-cyano-4-hydroxypyridine 
• 869802-74-4 2-chloro-3-cyano-4-hydroxypyridine 
• 147992-83-4 3-amino-4-phenylaminothieno[2,3-b]pyridine-2-carboxylic acid amide 
• 635731-06-5 3-amino-4-(4-benzylpiperazin-1-yl)thieno[2,3-b]pyridine-2-carboxylic acid amide 
• 635731-04-3 3-amino-4-(4-nitrophenylamino)thieno[2,3-b]pyridine-2-carboxylic acid amide 
• 635731-99-6 2-bromo-3-cyano-4-(4'-methoxybenzyloxy)pyridine 
• 869802-74-4 2-chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile 
• 816454-34-9 N-(4-{[(4-phenoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]methyl}phenyl)acetamide 
• 816454-22-5 4-phenoxy-1H-pyrazolo[4,3-c]pyridin-3-amine 
• 902171-53-3 1,4-dihydro-1,2-dimethyl-4-oxo-nicotinic acid 
• 902171-52-2 1,4-dihydro-2-methyl-4-oxo-nicotinic acid 
• 902171-51-1 2-methyl-4-methoxy-nicotinonitrile 

Relevant articles and documents

An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines

An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines is described. The key intermediates, 4-alkoxy-2-chloro-3- cyanopyridines, were synthesized from a variety of alcohols by nucleophilic substitution with 3-cyano-2,4-dich

FUSED TRICYCLIC MGLUR1 ANTAGONISTS AS THERAPEUTIC AGENTS

In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, part

Synthesis of 1,4-dihydro-2-methyl-4-oxo-nicotinic acid: Ochiai's route failed

The synthesis of 1,4-dihydro-2-methyl- and 1,4-dihydro-1,2-dimethyl-4-oxo-nicotinic acids was accomplished following a route other than Ochiai's procedure, which yielded the isomer 1,6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester, and not the 4-oxo-derivative, as reported. Analytical data confirmed the identity of the two isomer oxo-nicotinic acids. UV-vis and potentiometric preliminary data showed that Al(III) does not form complexes with 1,6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester in solution, as expected, but with 1,4-dihydro-2-methyl-4-oxo-nicotinic acid.