2-Chloro-4-ethyl-6-phenylpyrimidine

Base Information

Chemical Name:2-Chloro-4-ethyl-6-phenylpyrimidine
CAS No.:86984-22-7
Molecular Formula:C12H11ClN2
Molecular Weight:218.68200
Hs Code.:
DSSTox Substance ID:DTXSID10522526
Wikidata:Q82387870

Synonyms:2-Chloro-4-ethyl-6-phenylpyrimidine;86984-22-7;DTXSID10522526

Suppliers and Price of 2-Chloro-4-ethyl-6-phenylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Chloro-4-ethyl-6-phenylpyrimidine

Chemical Property:

PSA：25.78000
LogP:3.35940
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:218.0610761
Heavy Atom Count:15
Complexity:192

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC(=NC(=N1)Cl)C2=CC=CC=C2

Technology Process of 2-Chloro-4-ethyl-6-phenylpyrimidine

There total 6 articles about 2-Chloro-4-ethyl-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 89967-19-1
4-ethyl-6-phenyl-2(1H)-pyrimidinone

: 86984-22-7
2-chloro-4-ethyl-6-phenylpyrimidine

Guidance literature:: With trichlorophosphate; for 3h; Heating;

Reference yield: 55.0%

: 10467-10-4
ethylmagnesium iodide

: 26032-72-4
2,4-dichloro-6-phenyl-pyrimidine

: 86984-22-7
2-chloro-4-ethyl-6-phenylpyrimidine

Guidance literature:: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; at 0 ℃;

Reference yield:

: phenylmagnesium bromide

: 86984-22-7
2-chloro-4-ethyl-6-phenylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / dichloro-1,3-bis(diphenylphosphinopropane)nickel(II) / diethyl ether / 0 °C

2: 84 percent / triethylamine / toluene / 5 h / Heating

3: 55 percent / dichloro-1,3-bis(diphenylphosphinopropane)nickel(II) / diethyl ether / 0 °C

With triethylamine; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; toluene;