4-Aminotetrahydropyran

Base Information

• Chemical Name: 4-Aminotetrahydropyran
• CAS No.: 38041-19-9
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 29321900
• Mol file: 38041-19-9.mol

Synonyms:Pyran-4-amine,tetrahydro- (7CI);(4H-Tetrahydropyran-4-yl)amine;4-Aminotetrahydro-2H-pyran;4-Aminotetrahydropyran;4-Oxacyclohexylamine;Tetrahydro-2H-pyran-4-ylamine;Tetrahydropyran-4-ylamine;

Chemical Property of 4-Aminotetrahydropyran

Chemical Property:

• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: n20/D 1.463
• Boiling Point: 151.4 °C at 760 mmHg
• PKA: 9.63±0.20(Predicted)
• Flash Point: 49.3 °C
• PSA: 35.25000
• Density: 0.962 g/cm³
• LogP: 0.82440
• Storage Temp.: Store under Argon or Nitrogen

Purity/Quality:

98%, ^*data from raw suppliers

4-Aminotetrahydropyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 10-34-41-22-37/18
• Safety Statements: 16-26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Description: 4-Aminotetrahydropyran contains the tetrahydropyran ring, which is the most frequently reported three-dimensional ring system in marketed drugs, and is second only to the phenyl ring when two-dimensional rings are included. It can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer. Its scaffold is very useful in the drug discovery for cancer treatment.

Technology Process of 4-Aminotetrahydropyran

There total 15 articles about 4-Aminotetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

Tetrahydro-pyran-4-ol (2081-44-9) → 4-aminotetrahydropyran (38041-19-9)

Guidance literature:

With ammonium hydroxide; at 80 ℃; for 5h; Temperature;

Reference yield: 91.8%

tetrahydro-pyran-4-carboxylic acid amide (344329-76-6) → 4-aminotetrahydropyran (38041-19-9)

Guidance literature:

With sodium hypobromide; sodium hydroxide; In water; at 5 - 50 ℃; for 3h; Temperature;

Reference yield: 88.0%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 4-aminotetrahydropyran (38041-19-9)

Guidance literature:

Tetrahydro-4H-pyran-4-one; With ammonium formate; In methanol; water; at 20 ℃;

With palladium on activated charcoal; In methanol; water; at 20 ℃;

upstream raw materials:

tetrahydro-2H-pyran-4-carboxylic acid

tetrahydro-pyran-4-carboxylic acid amide

tetrahydropyran-4-one oxime

diethyl ether

Downstream raw materials:

N,N-dimethyl-N-tetrahydro-2H-pyran-4-ylamine

N-(tetrahydro-2H-pyran-4-yl)benzamide

[7-(2,6-Difluorophenyl)-2-(tetrahydro-pyran-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-(4-fluorophenyl)-methanone

4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate

Refernces

• 1、 -. "Preparation method of important intermediate 4-aminotetrahydropyran". Paragraph 0019-0025; 0026-0032; 0033-0039; 0040-0053; 0055. . Retrieved 2018/12/14.
• 2、 Sch?fer, Christian,Ni?anci, Bilal,Bere, Matthew P.,Da?tan, Arif,T?r?k, Béla. "Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source". . p. 3127 - 3133. Retrieved 2016/09/09.