D-Phe-OBzl HCl

Base Information

• Chemical Name: D-Phe-OBzl HCl
• CAS No.: 87004-78-2
• Molecular Formula: C16H17NO2.ClH
• Molecular Weight: 291.777
• Mol file: 87004-78-2.mol

Synonyms:D-Phenylalanine benzyl ester hydrochloride;D-Phe-OBzl*HCl;

Chemical Property of D-Phe-OBzl HCl

Chemical Property:

• PSA: 52.32000
• LogP: 3.80210
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

D-phenylalaninebenzylesterhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Phe-OBzl HCl

There total 6 articles about D-Phe-OBzl HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid benzyl ester (138168-65-7) → (R)-2-amino-3-phenylpropanoic acid benzyl ester hydrochloride (87004-78-2)

Guidance literature:

With hydrogenchloride; acetic acid; methoxybenzene; for 0.75h; Ambient temperature;

DOI:10.1021/jm00088a028

Reference yield:

phenylalanine benzyl ester hydrochloride (58780-66-8) → L-phenylalanine benzyl ester hydrochloride (2462-32-0) + (R)-2-amino-3-phenylpropanoic acid benzyl ester hydrochloride (87004-78-2)

Guidance literature:

With chiral stationary phase including isopropyl-functionalized CF₆; In ethanol; n-heptane; trifluoroacetic acid; at 20 ℃; Purification / work up;

Reference yield:

Boc-D-Phe-OH (18942-49-9) → (R)-2-amino-3-phenylpropanoic acid benzyl ester hydrochloride (87004-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 34 percent / dicyclohexylamine (DCHA) / dimethylformamide / 20 h / Ambient temperature

2: 98 percent / 1.7 N HCl/glacial HOAc, anisole / 0.75 h / Ambient temperature

With hydrogenchloride; acetic acid; methoxybenzene; N-cyclohexyl-cyclohexanamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00088a028

upstream raw materials:

(R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid benzyl ester

Boc-D-Phe-OH

benzyl bromide

phenylalanine benzyl ester hydrochloride

Downstream raw materials:

bis

benzyl (R)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-3-phenylpropanoate

BOC-6-aminohexanoyl-D-phenylalanine

bis