2-Propanol, 1-azido-3-(1-naphthalenyloxy)-

Base Information

• Chemical Name: 2-Propanol, 1-azido-3-(1-naphthalenyloxy)-
• CAS No.: 87102-64-5
• Molecular Formula: C13H13N3O2
• Molecular Weight: 243.265
• DSSTox Substance ID: DTXSID00444081
• Mol file: 87102-64-5.mol

Synonyms:87102-64-5;2-Propanol, 1-azido-3-(1-naphthalenyloxy)-;rac-1-Azido-3-(1-naphthalenyloxy)-2-propanol;1-azido-3-naphthalen-1-yloxypropan-2-ol;1-AZIDO-3-(NAPHTHALEN-1-YLOXY)PROPAN-2-OL;DTXSID00444081;AKOS030254752;FT-0662445

Chemical Property of 2-Propanol, 1-azido-3-(1-naphthalenyloxy)-

Chemical Property:

• PSA: 79.21000
• LogP: 2.34256
• Solubility.: Dichloromethane
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 243.100776666
• Heavy Atom Count: 18
• Complexity: 305

Purity/Quality:

99% ^*data from raw suppliers

rac-1-Azido-3-(1-naphthalenyloxy)-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2OCC(CN=[N+]=[N-])O
• Uses: Intermediate in the preparation of Propranolol.

Technology Process of 2-Propanol, 1-azido-3-(1-naphthalenyloxy)-

There total 4 articles about 2-Propanol, 1-azido-3-(1-naphthalenyloxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(1-naphthyloxy)-1,2-epoxypropane (2461-42-9) → (2RS)-1-(1'-naphthoxy)-3-azido-2-propanol (87102-64-5)

Guidance literature:

With sodium azide; ammonium chloride; In methanol; water; Heating;

DOI:10.1080/00397919808004470

Reference yield:

α-naphthol (90-15-3) → (2RS)-1-(1'-naphthoxy)-3-azido-2-propanol (87102-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Dowex resin (chloride form), 2.) NaH / 1.) reflux, 1 h, 2.) THF

2: 72.4 percent / NaN₃, NH₄Cl / H₂O / 0.5 h / Heating

With sodium azide; Dowex resin (chloride form); sodium hydride; ammonium chloride; In water;

DOI:10.1021/jm00366a005

Reference yield:

α-naphthol (90-15-3) → (2RS)-1-(1'-naphthoxy)-3-azido-2-propanol (87102-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 3 h / Reflux

2: sodium azide / ethanol; water / 1 h

With sodium azide; potassium carbonate; In ethanol; water;

DOI:10.1016/j.molstruc.2021.130038

upstream raw materials:

3-(1-naphthyloxy)-1,2-epoxypropane

α-naphthol

Downstream raw materials:

(S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol

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