5H-Pyrrolo[3,2-d]pyrimidine-6-carboxylic acid, 4-phenoxy-

Base Information

Chemical Name:5H-Pyrrolo[3,2-d]pyrimidine-6-carboxylic acid, 4-phenoxy-
CAS No.:871027-35-9
Molecular Formula:C13H9N3O3
Molecular Weight:255.233
Hs Code.:

Synonyms:

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Chemical Property of 5H-Pyrrolo[3,2-d]pyrimidine-6-carboxylic acid, 4-phenoxy-

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Technology Process of 5H-Pyrrolo[3,2-d]pyrimidine-6-carboxylic acid, 4-phenoxy-

There total 5 articles about 5H-Pyrrolo[3,2-d]pyrimidine-6-carboxylic acid, 4-phenoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 871027-34-8
4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine-6-carbaldehyde

: 871027-35-9
4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1021/jm2008634

Reference yield:

: 871027-32-6
4-(3,3-diethoxyprop-1-yn-1-yl)-6-phenoxypyrimidin-5-amine

: 871027-35-9
4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

3: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; potassium tert-butylate; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/jm2008634

Reference yield:

: 871024-05-4
4-iodo-6-phenoxypyrimidine-5-amine

: 871027-35-9
4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 16.5 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

4: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; sodium dihydrogenphosphate; copper(l) iodide; potassium tert-butylate; triethylamine; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile; 1: Sonogashira coupling;
DOI:10.1021/jm2008634