[3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane

Base Information

• Chemical Name: [3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane
• CAS No.: 87109-17-9
• Molecular Formula: C19H23O3P
• Molecular Weight: 330.364
• DSSTox Substance ID: DTXSID00518478
• Nikkaji Number: J2.166.727G
• Wikidata: Q82381175
• Mol file: 87109-17-9.mol

Synonyms:87109-17-9;DTXSID00518478;[3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane

Chemical Property of [3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane

Chemical Property:

• PSA: 45.34000
• LogP: 3.54370
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 330.13848159
• Heavy Atom Count: 23
• Complexity: 383

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(OCCO1)CCCP(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of [3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane

There total 12 articles about [3-(2-Methyl-1,3-dioxolan-2-yl)propyl](oxo)diphenyl-lambda~5~-phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-chloro-4-(1,3-dioxolane)-n-pentane (5978-08-5) + ethydiphenylphosphine oxide (1733-57-9) → 1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane (87109-17-9)

Guidance literature:

at 140 ℃;

Reference yield:

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → 1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane (87109-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / HI / H₂O

2: 70 percent / toluene-p-sulphonic acid / toluene / 24 h / Heating

3: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux, 2 h

With sodium hydroxide; hydrogen iodide; toluene-4-sulfonic acid; In water; toluene;

Reference yield:

5-iodo-2-pentanone (3695-29-2) → 1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane (87109-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid

2: NaOH

With sodium hydroxide; toluene-4-sulfonic acid;

DOI:10.1016/j.tet.2005.02.018

upstream raw materials:

1-chloro-4-(1,3-dioxolane)-n-pentane

triphenylphosphine

ethydiphenylphosphine oxide

ethylene-cetal de la bromo-5 pentanone-2

Downstream raw materials:

2-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

5-diphenylphosphinoyl-6-hydroxydecan-2-one ethylene acetal

5-diphenylphosphinoyl-6-hydroxydecan-2-one ethylene acetal