8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 2,3-bis(4-methylphenyl)-, phenyl ester, (1R,5S)-

Base Information

Chemical Name:8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 2,3-bis(4-methylphenyl)-, phenyl ester, (1R,5S)-
CAS No.:871228-48-7
Molecular Formula:C28H27NO2
Molecular Weight:409.528
Hs Code.:

Synonyms:

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Chemical Property of 8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 2,3-bis(4-methylphenyl)-, phenyl ester, (1R,5S)-

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Technology Process of 8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 2,3-bis(4-methylphenyl)-, phenyl ester, (1R,5S)-

There total 9 articles about 8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 2,3-bis(4-methylphenyl)-, phenyl ester, (1R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871228-43-2
2,3-di(4-methylphenyl)-2-tropene

: 1885-14-9
phenyl chloroformate

: 871228-48-7
(R)-N-phenoxycarbonyl-2,3-di-(4-methylphenyl)-2-tropene

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0582423

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 871228-48-7
(R)-N-phenoxycarbonyl-2,3-di-(4-methylphenyl)-2-tropene

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

1.2: 92 percent / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

3.1: aq. potassium hydroxide / 0.5 h / Heating

4.1: diphenylphosphorylazide; triethylamine / toluene / Heating

5.1: toluene / 8 h / Heating

6.1: 1.06 g / aq. HCl / 1 h / Heating

7.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

7.2: 34 percent / tetrahydrofuran / 23 h / 0 - 20 °C

8.1: 84 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / Heating

9.1: NaHCO₃ / CH₂Cl₂ / 20 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; cesium fluoride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm0582423

Reference yield:

: 168143-65-5
methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate

: 871228-48-7
(R)-N-phenoxycarbonyl-2,3-di-(4-methylphenyl)-2-tropene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

2.1: aq. potassium hydroxide / 0.5 h / Heating

3.1: diphenylphosphorylazide; triethylamine / toluene / Heating

4.1: toluene / 8 h / Heating

5.1: 1.06 g / aq. HCl / 1 h / Heating

6.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

6.2: 34 percent / tetrahydrofuran / 23 h / 0 - 20 °C

7.1: 84 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / Heating

8.1: NaHCO₃ / CH₂Cl₂ / 20 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; cesium fluoride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm0582423