Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]-

Base Information

• Chemical Name: Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]-
• CAS No.: 87165-92-2
• Molecular Formula: C21H18N2O3
• Molecular Weight: 346.386
• DSSTox Substance ID: DTXSID60455592
• Wikidata: Q82277669
• Mol file: 87165-92-2.mol

Synonyms:87165-92-2;Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]-;DTXSID60455592

Chemical Property of Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]-

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 346.13174244
• Heavy Atom Count: 26
• Complexity: 474

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)CC3=CC=CC=N3

Technology Process of Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]-

There total 1 articles about Benzamide, 4-methoxy-N-[2-(2-pyridinylacetyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-picoline (109-06-8) + methyl 2-[(4-methoxybenzoyl)amino]benzoate (37619-28-6) → 4-methoxy-N-<2-(2-pyridinylacetyl)phenyl>benzamide (87165-92-2)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) hexane, THF, 2.) hexane, THF, 20 deg C, 15 min;

DOI:10.1002/jhet.5570300321

Reference yield: 81.0%

4-methoxy-N-<2-(2-pyridinylacetyl)phenyl>benzamide (87165-92-2) → 4-methoxy-N-<2-(2-piperidinylacetyl)phenyl>benzamide hydrochloride

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In acetic acid; at 23 ℃; for 18h; under 760 Torr;

DOI:10.1002/jhet.5570300321

Reference yield:

4-methoxy-N-<2-(2-pyridinylacetyl)phenyl>benzamide (87165-92-2) → 4-methoxy-N-<2-<1-hydroxy-2-(2-pyridinyl)ethyl>phenyl>benzamide (153707-63-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1002/jhet.5570300321

upstream raw materials:

α-picoline

methyl 2-[(4-methoxybenzoyl)amino]benzoate

Downstream raw materials:

4-methoxy-N-<2-<1-hydroxy-2-(2-pyridinyl)ethyl>phenyl>benzamide

encainide

N-{2-[1-Hydroxy-2-(1-methyl-1,2,5,6-tetrahydro-pyridin-2-yl)-ethyl]-phenyl}-4-methoxy-benzamide