methyl 2-[(4-methoxybenzoyl)amino]benzoate

Base Information

• Chemical Name: methyl 2-[(4-methoxybenzoyl)amino]benzoate
• CAS No.: 37619-28-6
• Molecular Formula: C16H15NO4
• Molecular Weight: 285.299
• Mol file: 37619-28-6.mol

Synonyms:p-anisoyl amide of methyl anthranilate;methyl 2-(4-methoxybenzamido)benzoate;methyl N-(4-methoxybenzoyl)anthranilate;N-(4-methoxy-benzoyl)-anthranilic acid methyl ester;methyl N-p-anisoyl anthranilate;N-(4-Methoxy-benzoyl)-anthranilsaeure-methylester;

Chemical Property of methyl 2-[(4-methoxybenzoyl)amino]benzoate

Chemical Property:

• PSA: 64.63000
• LogP: 2.80710

Purity/Quality:

METHYL 2-((4-METHOXYBENZOYL)AMINO)BENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-[(4-methoxybenzoyl)amino]benzoate

There total 3 articles about methyl 2-[(4-methoxybenzoyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ methyl 2-[(4-methoxybenzoyl)amino]benzoate (37619-28-6)

Guidance literature:

Reference yield: 84.0%

4-methoxy-benzoyl chloride (100-07-2) + 2-carbomethoxyaniline (134-20-3) → methyl 2-[(4-methoxybenzoyl)amino]benzoate (37619-28-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm990327e

Reference yield:

4-methoxybenzoic acid (100-09-4) → methyl 2-[(4-methoxybenzoyl)amino]benzoate (37619-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 2 h / 20 °C

2: dichloromethane / 20 h / 20 °C

With thionyl chloride; In dichloromethane;

DOI:10.1007/s00044-012-0269-6

upstream raw materials:

4-methoxy-benzoyl chloride

2-carbomethoxyaniline

4-methoxybenzoic acid

Downstream raw materials:

4-methoxy-N-<2-<1-hydroxy-2-(2-pyridinyl)ethyl>phenyl>benzamide

N-{2-[1-Hydroxy-2-(1-methyl-1,2,5,6-tetrahydro-pyridin-2-yl)-ethyl]-phenyl}-4-methoxy-benzamide

encainide

2-[(4-methoxybenzoyl)amino]benzoic acid

Refernces

• 1、 Prashanth,Revanasiddappa. "Synthesis of some new glutamine linked 2,3-disubstituted quinazolinone derivatives as potent antimicrobial and antioxidant agents". . p. 2665 - 2676. Retrieved 2013/07/26.
• 2、 Hsieh, Pei-Wen,Hwang, Tsong-Long,Wu, Chin-Chung,Chiang, Shin-Zan,Wu, Chung-I,Wu, Yang-Chang. "The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents". . p. 1812 - 1817. Retrieved 2007/10/03.