(R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL

Base Information

• Chemical Name: (R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL
• CAS No.: 14898-86-3
• Molecular Formula: C10H14O
• Molecular Weight: 150.221
• Hs Code.: 2906299090
• Mol file: 14898-86-3.mol

Synonyms:Benzenemethanol, a-(1-methylethyl)-,(R)-;Benzyl alcohol, a-isopropyl-, (R)-(+)- (8CI);(+)-(aR)-a-(1-Methylethyl)benzenemethanol;(+)-a-Isopropylbenzylalcohol;(1R)-2-Methyl-1-phenylpropan-1-ol;(R)-(+)-2-Methyl-1-phenyl-1-propanol;(R)-1-Phenyl-2-methyl-1-propanol;(R)-1-Phenyl-2-methylpropanol;(R)-2-Methyl-1-phenyl-1-propanol;(R)-a-(1-Methylethyl)benzenemethanol;(R)-a-Isopropylbenzylalcohol;

Chemical Property of (R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL

Chemical Property:

• Vapor Pressure: 0.0678mmHg at 25°C
• Refractive Index: n20/D 1.513(lit.)
• Boiling Point: 219.8 °C at 760 mmHg
• PKA: 14.29±0.20(Predicted)
• Flash Point: 86.7 °C
• PSA: 20.23000
• Density: 0.976 g/cm³
• LogP: 2.37600
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.
• Hazard Codes: R22:Harmful if swallowed.
• Statements: 22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL

There total 63 articles about (R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenyl isopropyl ketone (611-70-1) → (R)-2-methyl-1-phenylpropan-1-ol (14898-86-3)

Guidance literature:

With potassium tert-butylate; hydrogen; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); (R)-Ph-BINAN-H-Py; In isopropyl alcohol; at 25 ℃; for 18h; under 38000 Torr;

DOI:10.1021/ja062451a

Reference yield: 95.0%

diisopropyl zinc (625-81-0) + benzaldehyde (100-52-7) → (R)-2-methyl-1-phenylpropan-1-ol (14898-86-3)

Guidance literature:

With 5-Deoxy-1,2-O-isopropylidene-5-morpholino-α-D-xylofuranose; In toluene; at 0 ℃; for 4h;

DOI:10.1016/S0957-4166(00)00253-6

Reference yield: 94.0%

phenyl isopropyl ketone (611-70-1) → (R)-2-methyl-1-phenylpropan-1-ol (14898-86-3) + (S)-2-methyl-1-phenylpropan-1-ol (34857-28-8)

Guidance literature:

With trans-[OsCl₂(py){2,6-bis[4’-(S)-isopropyloxazolin-2-yl]pyridine}]; caesium carbonate; In isopropyl alcohol; at 82 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.mcat.2018.07.002

upstream raw materials:

(2-methyl-1-propenyl)-benzene

1-acetoxy-1-phenyl-2-methylpropane

rac-2-methyl-1-phenylpropan-1-ol

(-)-(S)-N,N-dimethyl-1-phenylethylamine

Downstream raw materials:

(R)-2-methyl-1-phenylpropyl acetate

(R)-1-cyclohexyl-2-methylpropanol

(E)-2-Methyl-3-((R)-2-methyl-1-phenyl-propoxy)-propenal

(R)-Fluoro-phenyl-acetic acid (R)-2-methyl-1-phenyl-propyl ester