Glycine, N-acetyl-N-(2-methoxyethyl)glycyl-N-(phenylmethyl)glycyl-N-(2-methoxy ethyl)glycyl-N-(phenylmethyl)-, 4-[(aminoiminomethyl)amino]phenyl ester

Base Information

• Chemical Name: Glycine, N-acetyl-N-(2-methoxyethyl)glycyl-N-(phenylmethyl)glycyl-N-(2-methoxy ethyl)glycyl-N-(phenylmethyl)-, 4-[(aminoiminomethyl)amino]phenyl ester
• CAS No.: 872522-15-1
• Molecular Formula: C37H47N7O8
• Molecular Weight: 717.822
• Mol file: 872522-15-1.mol

Synonyms:

Chemical Property of Glycine, N-acetyl-N-(2-methoxyethyl)glycyl-N-(phenylmethyl)glycyl-N-(2-methoxy ethyl)glycyl-N-(phenylmethyl)-, 4-[(aminoiminomethyl)amino]phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-acetyl-N-(2-methoxyethyl)glycyl-N-(phenylmethyl)glycyl-N-(2-methoxy ethyl)glycyl-N-(phenylmethyl)-, 4-[(aminoiminomethyl)amino]phenyl ester

There total 3 articles about Glycine, N-acetyl-N-(2-methoxyethyl)glycyl-N-(phenylmethyl)glycyl-N-(2-methoxy ethyl)glycyl-N-(phenylmethyl)-, 4-[(aminoiminomethyl)amino]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-phenol (123-30-8) → ({2-[[2-({2-[Acetyl-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetyl]-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetic acid 4-guanidino-phenyl ester (872522-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 20 °C

2: N,N'-diisopropylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 8 h

3: TFA

With dmap; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja055105m

Reference yield:

tert-butyl N-[{[(tert-butoxy)carbonyl]imino}[(4-hydroxyphenyl)amino]methyl]carbamate (226087-02-1) → ({2-[[2-({2-[Acetyl-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetyl]-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetic acid 4-guanidino-phenyl ester (872522-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N'-diisopropylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 8 h

2: TFA

With dmap; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;

DOI:10.1021/ja055105m

Reference yield:

C47H63N7O12 → ({2-[[2-({2-[Acetyl-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetyl]-(2-methoxy-ethyl)-amino]-acetyl}-benzyl-amino)-acetic acid 4-guanidino-phenyl ester (872522-15-1)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1021/ja055105m

upstream raw materials:

4-amino-phenol

tert-butyl N-[{[(tert-butoxy)carbonyl]imino}[(4-hydroxyphenyl)amino]methyl]carbamate