8-oxoypalMatine

Base Information

Chemical Name:8-oxoypalMatine
CAS No.:19716-59-7
Molecular Formula:C21H21NO5
Molecular Weight:367.401
Hs Code.:
Mol file:19716-59-7.mol

Synonyms:2,3,9,10-tetramethoxy-8-oxoprotoberberine;5,6-dihydro-2,3,9,10-tetramethoxy-8H-dibenzo[a,g]quinolizin-8-one;2,3,9,10-tetramethoxy-8-oxo-berberine;8-Oxypalmatine;8-oxopalmatine;oxypseudopalmatine;2,3,9,10-Tetramethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolin-8-one;5,6-dihydro-2,3,9,10-tetramethoxy-8H-dibenzoquinolizin-8-one;

Suppliers and Price of 8-oxoypalMatine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
8-?Oxopalmatine
2.5mg
$ 195.00

Arctom
8-Oxypalmatine ≥98%
5mg
$ 498.00

Total 12 raw suppliers

Chemical Property of 8-oxoypalMatine

Chemical Property:

Melting Point:183-184℃ (methanol )
PSA：58.92000
Density:1.32±0.1 g/cm3 (20 oC 760 Torr)
LogP:3.25900

Purity/Quality:

99% ^*data from raw suppliers

8-?Oxopalmatine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 8-?Oxopalmatine is a derivative of 8-?oxocoptisine which shows potent promise in reversing effects against human cancer cells displaying multidrug resistance. Natural photoberberine alkaoid.

Technology Process of 8-oxoypalMatine

There total 3 articles about 8-oxoypalMatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63375-81-5
2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine

: 19716-59-7
8-oxypalmatine

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / chloroform / 20 h / 20 °C / Inert atmosphere

2: carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; silver hexafluoroantimonate; zinc diacetate / 2,2,2-trifluoroethanol / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube

3: palladium diacetate; potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube

With silver hexafluoroantimonate; carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; zinc diacetate; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.0c02016

Reference yield:

: 26067-60-7
2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline

: 19716-59-7
8-oxypalmatine

Guidance literature:: With sodium hydroxide;
DOI:10.1002/ardp.19312694004

Reference yield:

: 108585-32-6
3',4'-dihydro-6,6',7,7'-tetramethoxy-spiro<2H-indene-2,1'(2'H)-isoquinolin>-1(3H)-one

: 19716-59-7
8-oxypalmatine

: 2934-97-6,84-38-8
(+/-)-tetrahydropalmatine

Guidance literature:: With sodium tetrahydroborate; Yield given. Multistep reaction. Yields of byproduct given; 1.) EtOH, irradiation, 25-30 deg C, 2.5 h; 2.) MeOH, room temperature, 4.5 h;;
DOI:10.1248/cpb.34.3919