63375-81-5

Basic information

• Product Name: 2-(2-BROMO-4,5-DIMETHOXYPHENYL)ETHANAMINE HYDROCHLORIDE
• Synonyms: Phenethylamine,2-bromo-4,5-dimethoxy- (6CI,7CI); 2-(2-bromo-4,5-dimethoxyphenyl)ethylamine;2-Bromo-4,5-dimethoxyphenethylamine
• CAS NO: 63375-81-5
• Molecular Formula: C₁₀H₁₄BrNO₂
• Molecular Weight: 260.14
• Mol File: 63375-81-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 325.6°Cat760mmHg
• Flash Point: 150.7°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 0.000227mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 2-(2-BROMO-4,5-DIMETHOXYPHENYL)ETHANAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-BROMO-4,5-DIMETHOXYPHENYL)ETHANAMINE HYDROCHLORIDE(63375-81-5)
• EPA Substance Registry System: 2-(2-BROMO-4,5-DIMETHOXYPHENYL)ETHANAMINE HYDROCHLORIDE(63375-81-5)

Safety Data

• Hazardous Substances Data: 63375-81-5(Hazardous Substances Data)

Usage

General Description

2-(2-Bromo-4,5-dimethoxyphenyl)ethanamine hydrochloride is a chemical compound that belongs to the class of substituted amphetamines. It is an organic compound with the molecular formula C10H14BrClNO2. 2-(2-BROMO-4,5-DIMETHOXYPHENYL)ETHANAMINE HYDROCHLORIDE is commonly used as a research chemical and has been studied for its potential applications in the fields of medicine and neuroscience. It is also known to have psychoactive effects and has been investigated for its potential use as a drug for treating various neurological and psychiatric disorders. However, it is important to note that the use of this compound for any purpose should be carefully regulated and controlled due to its potential for abuse and harm.

InChI:InChI=1/C10H14BrNO2/c1-13-9-5-7(3-4-12)8(11)6-10(9)14-2/h5-6H,3-4,12H2,1-2H3

Upstream product

• 7726-95-6 bromine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 64-19-7 acetic acid 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 74064-26-9 N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]acetamide 
• 69327-12-4 1-bromo-2-(2-bromoethyl)-4,5-dimethoxybenzene 
• 289507-36-4 2-(2-bromo-4,5-dimethoxyphenyl)ethyl alcohol 
• 90841-59-1 2-(2-bromo-4,5-dimethoxyphenyl)acetaldehyde 
• 67191-53-1 N-(3,4-Dimethoxyphenethyl)propionamide 
• 106469-78-7 tert-butyl (2-bromo-4,5-dimethoxyphenethyl)carbamate 
• 98062-25-0 tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 635-85-8 homoveratrylamine hydrochloride 

Downstream Products

• 72735-78-5 N-<2-(2-bromo-3,4-dimethoxyphenyl)ethyl>-4,5-dimethoxybenzamide 
• 190511-17-2 N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-2,3-didehydro-3-ethyl-6-heptyl-4-oxopiperidine 
• 190511-03-6 N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-2,3-didehydro-4-oxo-6-propylpiperidine 
• 190511-02-5 1-(2-bromo-4,5-dimethoxyphenethyl)-2-isopropyl-2,3-dihydropyridin-4(1H)-one 
• 337966-23-1 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-amine 
• 140616-37-1 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-phenyl-eth-(E)-ylidene]-amine 
• 496790-16-0 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-(2-methoxy-phenyl)-eth-(E)-ylidene]-amine 
• 764665-03-4 benzyl [2-(2-bromo-4,5-dimethoxyphenyl)ethyl]carbamate 
• 140616-38-2 Benzhydrylidene-[2-(2-bromo-4,5-dimethoxy-phenyl)-ethyl]-amine 
• 238740-84-6 N-<2-(2-bromo-4,5-dimethoxy)phenyl>ethyl(2-iodophenyl)acetamide 
• 1372870-55-7 [Pd(C,N-C₆H₂CH₂CH₂NH₂-6,(OMe)2-3,4)(N,N,N',N'-tetramethylethylenediamine)]Br 
• 1428797-01-6 ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylate 
• 1428797-02-7 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydroimidazo[2,1-a]isoquinoline-2-carboxylic acid 

Relevant articles and documents

L-DOPA Dioxygenase Activity on 6-Substituted Dopamine Analogues

Dioxygenase enzymes are essential protein catalysts for the breakdown of catecholic rings, structural components of plant woody tissue. This powerful chemistry is used in nature to make antibiotics and other bioactive materials or degrade plant material, but we have a limited understanding of the breadth and depth of substrate space for these potent catalysts. Here we report steady-state and pre-steady-state kinetic analysis of dopamine derivatives substituted at the 6-position as substrates of L-DOPA dioxygenase, and an analysis of that activity as a function of the electron-withdrawing nature of the substituent. Steady-state and pre-steady-state kinetic data demonstrate the dopamines are impaired in binding and catalysis with respect to the cosubstrate molecular oxygen, which likely afforded spectroscopic observation of an early reaction intermediate, the semiquinone of dopamine. The reaction pathway of dopamine in the pre-steady state is consistent with a nonproductive mode of binding of oxygen at the active site. Despite these limitations, L-DOPA dioxygenase is capable of binding all of the dopamine derivatives and catalyzing multiple turnovers of ring cleavage for dopamine, 6-bromodopamine, 6-carboxydopamine, and 6-cyanodopamine. 6-Nitrodopamine was a single-turnover substrate. The variety of substrates accepted by the enzyme is consistent with an interplay of factors, including the capacity of the active site to bind large, negatively charged groups at the 6-position and the overall oxidizability of each catecholamine, and is indicative of the utility of extradiol cleavage in semisynthetic and bioremediation applications.

CuI-catalyzed coupling of gem-dibromovinylanilides and sulfonamides: An efficient method for the synthesis of 2-amidoindoles and indolo[1,2-a] quinazolines

A Cu(I)-catalyzed, intermolecular protocol for the synthesis of 2-amidoindoles and tetrahydroindolo[1,2-a]quinazolines in shorter time and high yields is reported. The key highlight of this disclosure is the formation of 2-amidoindole and tetrahydroindolo[1,2-a]quinazoline moieties directly from gem-dibromovinylanilides and sulfonamides in a one-pot fashion through the in situ formation of ynamides followed by a base-promoted intramolecular hydroamidation.

Phosphane-free Pd0-catalyzed cycloamination and carbonylation with Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3: Preparation of benzocyclic amines and benzolactams

Phosphane-free Pd0-catalyzed intramolecular aromatic amination was studied. o-Halophenethylamines and 3-(o-halophenyl)propylamines were found to be transformed into indolines and quinolines in a catalytic system based on Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3. Application of the method to substrates containing isoquinoline rings- the 1-(o-bromobenzyl)-3,4-dihydroisoquinolines 6, the 1-(o-bromobenzyl)-1,2,3,4-tetrahydroisoquinolines 7, and the 1-(o-bromophenethyl)isoquinolines 9- provided the indolo[2,1-a]isoquinoline and dibenzo[a,f]quinolizine ring systems 8 and 10. Extension of the method to β-carbolines (compounds 11, 12, and 17) produced the benz[f]indolo[2,3-a] indolizine-13-ones 15 and the benz[f]indolo[2,3-a]quinolizine 18. The benzo[f]pyrido[3,4-a]indolizine and indolo[f]pyrido[3,4-a]indolizin-12-one ring systems 27 and 31 were built in a similar manner. It was also found that under an atmosphere of CO the same catalytic system produced the corresponding benzolactams, the isoquino[2,1-a][2,7]naphthyridine 34 and the indolo[2,3-a]pyrido[g]quinolizin-8-one 36 [(±)-dihydronauclefine] in good yields. Copyright