Technology Process of 2,4,12-Trioxa-13-silapentadec-9-ene,
8,10-diethyl-6,14,14-trimethyl-13,13-diphenyl-7-(phenylmethoxy)-,
(6R,7R,8R,9E)-
There total 11 articles about 2,4,12-Trioxa-13-silapentadec-9-ene,
8,10-diethyl-6,14,14-trimethyl-13,13-diphenyl-7-(phenylmethoxy)-,
(6R,7R,8R,9E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 87 percent / K2CO3 / methanol
2: (COCl)2; DMSO; triethylamine / CH2Cl2
3: 90 percent / DIBAL-H / CH2Cl2 / -78 °C
4: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C
5: 62 percent / CuI / diethyl ether / -50 - -40 °C
6: 52 percent / RuCl2(PPh3)3 / benzene
7: 76 percent / benzene / Heating
8: 84 percent / NaH / tetrahydrofuran
9: 94 percent / DIBAL-H
10: 91 percent / triethylamine
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; oxalyl dichloride; diethyl (2S,3S)-tartrate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
2: Swern oxidation / 3: Horner-Wittig reaction / 8: Horner-Wittig reaction;
DOI:10.1021/ol0521329
- Guidance literature:
-
Multi-step reaction with 7 steps
1: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C
2: 62 percent / CuI / diethyl ether / -50 - -40 °C
3: 52 percent / RuCl2(PPh3)3 / benzene
4: 76 percent / benzene / Heating
5: 84 percent / NaH / tetrahydrofuran
6: 94 percent / DIBAL-H
7: 91 percent / triethylamine
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; diethyl (2S,3S)-tartrate; sodium hydride; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; benzene;
4: Horner-Wittig reaction;
DOI:10.1021/ol0521329
