1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-

Base Information

Chemical Name:1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-
CAS No.:872625-18-8
Molecular Formula:C24H23F9N6
Molecular Weight:566.472
Hs Code.:

1H-1-Benzazepin-5-amine,
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl
-N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-

Synonyms:

Suppliers and Price of 1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)-

There total 1 articles about 1H-1-Benzazepin-5-amine, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2,3,4,5-tetrahydro-7,9-dimethyl -N-(2-methyl-2H-tetrazol-5-yl)-8-(trifluoromethyl)-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 872626-34-1
(S)-(3,5-bis-trifluoromethyl-benzyl)-(9-bromo-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine

: 13061-96-6
dihydroxy-methyl-borane

: 872625-18-8
(S)-(3,5-bis-trifluoromethyl-benzyl)-(7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine

Guidance literature:: (S)-(3,5-bis-trifluoromethyl-benzyl)-(9-bromo-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine; dihydroxy-methyl-borane; With cesium fluoride; In 1,4-dioxane; for 0.25h;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; for 3h;

Reference yield: 81.0%

: 872625-18-8
(S)-(3,5-bis-trifluoromethyl-benzyl)-(7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: (S)-tert-butyl 4-{5-[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepin-1-ylmethyl}-piperidine-1-carboxylate

Guidance literature:: (S)-(3,5-bis-trifluoromethyl-benzyl)-(7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine; tert butyl 4-formylpiperidine-1-carboxylate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;

Reference yield: 81.0%

: 5781-53-3
monomethyl oxalyl chloride

: 872625-18-8
(S)-(3,5-bis-trifluoromethyl-benzyl)-(7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine

: (S)-{5-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-oxo-acetic acid methyl ester

Guidance literature:: monomethyl oxalyl chloride; (S)-(3,5-bis-trifluoromethyl-benzyl)-(7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine; With pyridine; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;