Technology Process of L-Valine, 3-methyl-N-[[(phenylmethyl)amino]carbonyl]-,
2-(phenylmethyl)hydrazide
There total 3 articles about L-Valine, 3-methyl-N-[[(phenylmethyl)amino]carbonyl]-,
2-(phenylmethyl)hydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S)-2-(3-benzylureido)-3,3-dimethyl-butyric acid;
With
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
triethylamine;
In
ethyl acetate;
at 20 ℃;
for 0.5h;
benzylhydrazine dihydrochloride;
In
ethyl acetate;
at 20 ℃;
DOI:10.1021/jm050790t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aq. NaOH / dioxane / 0.17 h / 20 °C
1.2: dioxane / 18 h / 20 °C
2.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methylmorpholine / Et3N / ethyl acetate / 0.5 h / 20 °C
2.2: ethyl acetate / 20 °C
With
4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
triethylamine;
In
1,4-dioxane; ethyl acetate;
DOI:10.1021/jm050790t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aq. NaOH / dioxane / 0.17 h / 20 °C
1.2: dioxane / 18 h / 20 °C
2.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methylmorpholine / Et3N / ethyl acetate / 0.5 h / 20 °C
2.2: ethyl acetate / 20 °C
With
4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
triethylamine;
In
1,4-dioxane; ethyl acetate;
DOI:10.1021/jm050790t
