Chemical Property of Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-
Chemical Property:
- PSA：59.59000
- LogP:4.11960
- Storage Temp.:+2C to +8C
- XLogP3:4.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:289.05727796
- Heavy Atom Count:20
- Complexity:333
- Purity/Quality:
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97% *data from raw suppliers
GW 610 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C=C1)C2=NC3=C(S2)C=CC(=C3)F)OC
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Description
GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.
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Uses
GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity.
