Diethyl 2-(4-methoxyphenyl)malonate

Base Information

Chemical Name:Diethyl 2-(4-methoxyphenyl)malonate
CAS No.:23197-67-3
Molecular Formula:C14H18 O5
Molecular Weight:266.294
Hs Code.:2918990090
DSSTox Substance ID:DTXSID70382865
Nikkaji Number:J1.368.674B
Wikidata:Q82174332
Mol file:23197-67-3.mol

Synonyms:Diethyl 2-(4-methoxyphenyl)malonate;23197-67-3;Diethyl 4-methoxyphenyl malonate;diethyl 2-(4-methoxyphenyl)propanedioate;1,3-diethyl 2-(4-methoxyphenyl)propanedioate;2-(4-Methoxyphenyl)-malonic acid diethyl ester;MFCD04038965;ethyl 2-ethoxycarbonyl-2-(4-methoxyphenyl)acetate;tert-Boc-aminooxyacetic acid?;SCHEMBL1043694;Diethyl-2-p-methoxyphenylmalonate;DTXSID70382865;QXHBIWJHLHGDEO-UHFFFAOYSA-N;AKOS005259930;PS-7312;(4-Methoxyphenyl)malonic acid diethyl ester;CS-0099860;D76037;Propanedioic acid,2-(4-methoxyphenyl)-,1,3-diethyl ester

Suppliers and Price of Diethyl 2-(4-methoxyphenyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Diethyl2-(4-Methoxyphenyl)malonate
10g
$ 1230.00

SynQuest Laboratories
Diethyl 2-(4-methoxyphenyl)malonate
5 g
$ 184.00

SynQuest Laboratories
Diethyl 2-(4-methoxyphenyl)malonate
1 g
$ 48.00

SynQuest Laboratories
Diethyl 2-(4-methoxyphenyl)malonate
250 mg
$ 24.00

Crysdot
Diethyl2-(4-methoxyphenyl)malonate 97%
5g
$ 301.00

American Custom Chemicals Corporation
DIETHYL 2-(4-METHOXYPHENYL)MALONATE 95.00%
5G
$ 881.73

American Custom Chemicals Corporation
DIETHYL 2-(4-METHOXYPHENYL)MALONATE 95.00%
1G
$ 613.88

Total 8 raw suppliers

Chemical Property of Diethyl 2-(4-methoxyphenyl)malonate

Chemical Property:

Melting Point:72 °C
Boiling Point:345.8 °C at 760 mmHg
PKA:12.76±0.46(Predicted)
Flash Point:149.5 °C
PSA：61.83000
Density:1.125 g/cm³
LogP:1.90500
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:266.11542367
Heavy Atom Count:19
Complexity:276

Purity/Quality:

97% ^*data from raw suppliers

Diethyl2-(4-Methoxyphenyl)malonate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC=C(C=C1)OC)C(=O)OCC
Uses Diethyl 2-(4-Methoxyphenyl)malonate is an intermediate in the synthesis of 4-hydroxy felbamate (H942470). Diethyl 2-(4-Methoxyphenyl)malonate is a reagent in evaluating the structure-activity relationships of non-nucleoside adenosine kinase inhibitors of aminoarylarylethynylpyrimidines.

Technology Process of Diethyl 2-(4-methoxyphenyl)malonate

There total 14 articles about Diethyl 2-(4-methoxyphenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 105-53-3
diethyl malonate

: 23197-67-3
diethyl 2-(4-methoxyphenyl)malonate

Guidance literature:: With tri-tert-butyl phosphine; sodium hydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; for 3h;
DOI:10.1021/jo016226h

Reference yield: 91.0%

: 696-62-8
para-iodoanisole

: 105-53-3
diethyl malonate

: 23197-67-3
diethyl 2-(4-methoxyphenyl)malonate

Guidance literature:: With 2-Picolinic acid; copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201300860

Reference yield: 90.0%

: 623-12-1
4-chloromethoxybenzene

: 105-53-3
diethyl malonate

: 23197-67-3
diethyl 2-(4-methoxyphenyl)malonate

Guidance literature:: With potassium phosphate; (1-adamantyl)di(tert-butyl) phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 100 ℃;
DOI:10.1021/jo016226h