3-(4-Bromophenyl)-3-methyloxetane

Base Information

• Chemical Name: 3-(4-Bromophenyl)-3-methyloxetane
• CAS No.: 872882-97-8
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.101
• Hs Code.: 2932999099
• Mol file: 872882-97-8.mol

Synonyms:(2E)-3-(4-bromophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one;(E)-3-(4-bromophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one,3-(4-bromophenyl)-1-(2-hydroxyphenyl)-,(E);2-Propen-1-one,3-(4-bromophenyl)-1-(2-hydroxyphenyl);4-bromo-2'-hydroxy-trans-chalcone;2'-hydroxy-4-bromochalcone;(E)-2'-hydroxychalcone;3-(4-bromophenyl)-3-hydroxy-1-(2-hydroxyphenyl)prop-2-en-1-one;3-(4-bromo-phenyl)-3-methyl-oxetane;4-Brom-2'-hydroxy-trans-chalkon;

Chemical Property of 3-(4-Bromophenyl)-3-methyloxetane

Chemical Property:

• PSA: 9.23000
• LogP: 2.73700

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Bromophenyl)-3-methyloxetane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Bromophenyl)-3-methyloxetane

There total 16 articles about 3-(4-Bromophenyl)-3-methyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(4-bromophenyl)-2-methylpropane-1,3-diol (66810-01-3) → 3-(4-bromophenyl)-3-methyloxetane (872882-97-8)

Guidance literature:

2-(4-bromophenyl)-2-methylpropane-1,3-diol; With triphenylphosphine; In toluene; for 0.0833333h;

With diethylazodicarboxylate; In toluene; at 20 ℃; for 18h;

Reference yield: 81.0%

2-(4-Bromophenyl)-2,2-dimethoxyethane (53578-00-0) → 3-(4-bromophenyl)-3-methyloxetane (872882-97-8)

Guidance literature:

2-(4-Bromophenyl)-2,2-dimethoxyethane; With triphenylphosphine; In toluene; for 0.0833333h;

With diethylazodicarboxylate; In toluene; at 20 ℃; for 18h;

Reference yield: 56.0%

2-(3-(4-bromophenyl)oxetan-3-yl)acetaldehyde → 3-(4-bromophenyl)-3-methyloxetane (872882-97-8)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01236

upstream raw materials:

2-(4-Bromophenyl)-2,2-dimethoxyethane

2-(4-bromophenyl)-2-methylpropane-1,3-diol

triphenylphosphine

Ethyl 4-bromophenylacetate

Downstream raw materials:

(4-(3-methyloxetan-3-yl)phenyl)boronic acid

4-(3-methyloxetan-3-yl)benzoic acid

6-(4-(3-methyloxetan-3-yl)phenyl)nicotinonitrile

(5R,8S,11R,13S,14S,17S)-5',5',13-trimethyl-11-[4-(3-methyloxetan-3-yl)phenyl]-17-(pentafluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17(4H)-diol