4-BROMOACETOPHENONE DIMETHYL ACETAL

Base Information

• Chemical Name: 4-BROMOACETOPHENONE DIMETHYL ACETAL
• CAS No.: 53578-00-0
• Molecular Formula: C10H13BrO2
• Molecular Weight: 245.116
• Mol file: 53578-00-0.mol

Synonyms:2-(4-bromophenyl)-2-methylpropane-1,3-diol;1-bromo-4-(1,1-dimethoxyethyl)benzene;4-bromoacetophenone;4-BROMOACETOPHENONE DIMETHYL ACETAL;4-bromo-(1,1-dimethoxyethyl)-benzene;4-bromo-(1,1-dimethoxyethyl)benzene;

Chemical Property of 4-BROMOACETOPHENONE DIMETHYL ACETAL

Chemical Property:

• Boiling Point: 251.9±25.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 2.91460

Purity/Quality:

98% ^*data from raw suppliers

1-BROMO-4-(1,1-DIMETHOXYETHYL)BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-BROMOACETOPHENONE DIMETHYL ACETAL

There total 7 articles about 4-BROMOACETOPHENONE DIMETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

methanol (67-56-1) + para-bromoacetophenone (99-90-1) + trimethyl orthoformate (149-73-5) → 2-(4-Bromophenyl)-2,2-dimethoxyethane (53578-00-0)

Guidance literature:

With povidone-iodine; at 30 ℃; for 6h; Green chemistry;

DOI:10.1016/j.tet.2021.132250

Reference yield: 99.0%

methanol (67-56-1) + para-bromoacetophenone (99-90-1) → 2-(4-Bromophenyl)-2,2-dimethoxyethane (53578-00-0)

Guidance literature:

With toluene-4-sulfonic acid; orthoformic acid triethyl ester; at 60 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2011.05.011

Reference yield: 94.0%

para-bromoacetophenone (99-90-1) + trimethyl orthoformate (149-73-5) → 2-(4-Bromophenyl)-2,2-dimethoxyethane (53578-00-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃;

DOI:10.1021/jacs.8b05804

upstream raw materials:

para-bromoacetophenone

trimethyl orthoformate

methanol

p-toluenesulfonic acid monohydrate

Downstream raw materials:

1-(4-(pyridin-4-yl)phenyl)ethan-1-one

methanol

para-bromoacetophenone

(rac.)-1-bromo-4-(1-methoxyethyl)benzene

Refernces

• 1、 Rossolini, Thomas,Ferko, Branislav,Dixon, Darren J.. "Photocatalytic Reductive Formation of α-Tertiary Ethers from Ketals". supporting information. p. 6668 - 6673. Retrieved 2019/09/03.
• 2、 Blümel, Marcus,Nagasawa, Shota,Blackford, Katherine,Hare, Stephanie R.,Tantillo, Dean J.,Sarpong, Richmond. "Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity". supporting information. p. 9291 - 9298. Retrieved 2018/07/15.