7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one

Base Information

Chemical Name:7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one
CAS No.:872973-93-8
Molecular Formula:C20H9Cl3F2N2O
Molecular Weight:437.66
Hs Code.:
DSSTox Substance ID:DTXSID90469662
Nikkaji Number:J2.279.949E
Wikidata:Q82297483

Synonyms:872973-93-8;AGN-PC-00CXLT;DTXSID90469662

Suppliers and Price of 7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:435.974852
Heavy Atom Count:28
Complexity:614

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)Cl)N2C(=O)C=CC3=C(N=C(C=C32)Cl)C4=C(C=C(C=C4)F)F)Cl

Technology Process of 7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one

There total 13 articles about 7-Chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 872973-92-7
5,7-dichloro-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2-(1H)-one

: 144025-03-6
2,4-difluorophenylboronic acid

: 872973-93-8
7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one

: 5-chloro-1-(2,6-dichlorophenyl)-7-(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one

: 1-(2,6-dichlorophenyl)-5,7-bis(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one

Guidance literature:: With potassium phosphate; 1,3-bis(mesityl)imidazolium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 50 - 80 ℃; for 13.5h;
DOI:10.1021/jo0514927

Reference yield: 85.0%

: 913556-82-8
1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2(1H)-one 6-oxide

: 872973-93-8
7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one

Guidance literature:: With trichlorophosphate;
DOI:10.1021/jo061618f

Reference yield:

: methyl 5-[(4-methoxybenzyl)amino]-3,5-dioxopentanoate

: 872973-93-8
7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid monohydrate / toluene / 20 h / 117 °C

2: t-BuOK / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 3 h / 100 °C

3: POCl₃; Me₄NCl / 21 h / 140 °C

4: Cs₂CO₃ / Pd(dppf)Cl₂ / toluene / 1 h / 110 °C

With potassium tert-butylate; tetramethlyammonium chloride; caesium carbonate; toluene-4-sulfonic acid; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene; 4: Suzuki-Miyaura reaction;
DOI:10.1021/jo0514927