2-methyl-2,3-dihydro-1,4-phthalazinedione

Base Information

• Chemical Name: 2-methyl-2,3-dihydro-1,4-phthalazinedione
• CAS No.: 18393-54-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 18393-54-9.mol

Synonyms:N-methylphthalhydrazide;methylphthalhydrazide;2-Methyl-2,3-dihydro-phthalazin-1,4-dion;HMS561H22;2-methyl-1,2,3,4-tetrahydrophthalazine-1,4-dione;2-methyl-2,3-dihydrophthalazine-1,4-dione;

Chemical Property of 2-methyl-2,3-dihydro-1,4-phthalazinedione

Chemical Property:

• Vapor Pressure: 5.91E-06mmHg at 25°C
• Boiling Point: 364.6°Cat760mmHg
• Flash Point: 174.3°C
• PSA: 54.86000
• Density: 1.292g/cm³
• LogP: 0.22680

Purity/Quality:

97% ^*data from raw suppliers

2-methyl-1,2,3,4-tetrahydrophthalazine-1,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-2,3-dihydro-1,4-phthalazinedione

There total 13 articles about 2-methyl-2,3-dihydro-1,4-phthalazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

<3RS,4RS>-1-(4-methoxyphenyl)-4-(2-methoxythiazol-4-yl)-4-methyl-3-phthalimidoazetidin-2-one → 2-methyl-2,3-dihydro-phthalazine-1,4-dione (18393-54-9) + <3RS,4RS>-3-amino-1-(4-methoxyphenyl)-4-(2-methoxythiazol-4-yl)-4-methylazetidin-2-one

Guidance literature:

With methylhydrazine; In dichloromethane; ethyl acetate; for 96h; Ambient temperature;

DOI:10.1016/0040-4020(95)00158-5

Reference yield: 82.0%

phthalic anhydride (85-44-9) + methylhydrazine (60-34-4) → 2-methyl-2,3-dihydro-phthalazine-1,4-dione (18393-54-9)

Guidance literature:

With montmorillonite KSF; for 0.25h; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.05.052

Reference yield: 75.0%

4-<<2RS,3RS>-1-(4-methoxyphenyl)-2-methyl-4-oxo-3-phthalimidoazetidin-2-yl>-3-methylthiazol-2(3H)-one → 2-methyl-2,3-dihydro-phthalazine-1,4-dione (18393-54-9) + 4-<<2RS,3RS>-3-amino-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl>-3-methylthiazol-2(3H)-one

Guidance literature:

With methylhydrazine; In dichloromethane; for 96h; Ambient temperature;

DOI:10.1016/0040-4020(95)00158-5

upstream raw materials:

phthalic anhydride

methylhydrazine

acetic anhydride

2-[3-(4-Chloro-phenyl)-prop-2-ynyloxy]-isoindole-1,3-dione

Downstream raw materials:

N-acetyl-sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide)

sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide)

4-chloro-2-methylphthalazin-1-(2H)-one