1H-Imidazolium, 1-[[3,5-bis(1,1-dimethylethyl)-2-hydroxyphenyl]methyl]-3-(phenylmethyl)-, chloride

Base Information

• Chemical Name: 1H-Imidazolium, 1-[[3,5-bis(1,1-dimethylethyl)-2-hydroxyphenyl]methyl]-3-(phenylmethyl)-, chloride
• CAS No.: 873203-77-1
• Molecular Formula: C25H33N2O.Cl
• Molecular Weight: 413.003
• Mol file: 873203-77-1.mol

Synonyms:

Chemical Property of 1H-Imidazolium, 1-[[3,5-bis(1,1-dimethylethyl)-2-hydroxyphenyl]methyl]-3-(phenylmethyl)-, chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Imidazolium, 1-[[3,5-bis(1,1-dimethylethyl)-2-hydroxyphenyl]methyl]-3-(phenylmethyl)-, chloride

There total 1 articles about 1H-Imidazolium, 1-[[3,5-bis(1,1-dimethylethyl)-2-hydroxyphenyl]methyl]-3-(phenylmethyl)-, chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-benzylimidazole (4238-71-5) + 2,4-di-tertbutyl-6-chloromethylphenol (10193-84-7) → [1-OH-4,6-di-tert-butyl-2-CH2C3H3N2(benzyl)-C6H2]Cl (873203-77-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.jorganchem.2005.09.029

Reference yield: 70.0%

[1-OH-4,6-di-tert-butyl-2-CH2C3H3N2(benzyl)-C6H2]Cl (873203-77-1) + iron(II) bromide (7789-46-0) → [Fe(O-4,6-(C(CH3)3)2-C6H2-2-CH2NCHCHN(CH2Ph)C)2]

Guidance literature:

With Na[N(SiMe₃)2]; In tetrahydrofuran; (Ar); Schlenk technique; NaN(SiMe3)2 (2 equiv.) in THF added dropwise tosuspn. of chloride (1 equiv.) in THF at -20°C; stirred for 20 mi n; warmed to room temp. for 10 min; mixt. added to suspn. of FeBr2 (0.5 equiv.) in THF; stirred for 16 h; pumped; extd. (toluene); crystd. (Et2O/hexane, 0°C); elem. anal.;

DOI:10.1016/j.jorganchem.2006.01.031

Reference yield: 70.0%

[1-OH-4,6-di-tert-butyl-2-CH2C3H3N2(benzyl)-C6H2]Cl (873203-77-1) + 1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + dibromobis(triphenylphosphine)nickel(II) (36673-36-6,111408-20-9,14126-37-5,54053-52-0) → [Ni(O-4,6-di-tert-butyl-2-CH2C3H2N2(benzyl)-C6H2)2]*2(C4H8O2)

Guidance literature:

With NaN(Si(CH₃)3)2; In tetrahydrofuran; (Ar); addn. of suspn. of NaN(SiMe3)2 (2 equiv.) in THF to mixt. of C25H33ClN2O and THF at -78°C; stirring for 0.5 h; warming to room temp. for 10 min; addn. to suspn. of NiBr2(PPh3)2 in THF at -78°C; warming to room temp., stirring for 12h; filtration, evapn. to dryness; extn. with toluene; recrystn. from 1,4-dioxane/CH2Cl2 (5:1) at room temp.; elem. anal.;

DOI:10.1016/j.jorganchem.2005.09.029

upstream raw materials:

1-benzylimidazole

2,4-di-tertbutyl-6-chloromethylphenol