4238-71-5Relevant articles and documents
Improved methods for the synthesis and isolation of imidazolium based ionic salts
Ibrahim, Halliru,Bala, Muhammad Dabai
, p. 6351 - 6353 (2014)
Solvent-free reactions were used for the synthesis of a series of imidazolium-based ionic salts: 3,3′-[pyridine-2,6-diylbis(methylene)]bis(1-R-1H-imidazol-3-ium)chloride; (R = methyl, ethyl, butyl, isobutyl, hexyl, and benzyl). A simple and effective filtration process was used to isolate all the products in high purity and with yields ≥93% within a 24 h period. The highly pure ionic compounds which are precursors to N-heterocyclic carbene ligands used in catalysis were fully characterized as gray-white hygroscopic salts.
Azolium mediated N[sbnd]Heterocyclic carbene selenium adducts: Synthesis, cytotoxicity and molecular docking studies
Ashraf, Rizwan,Bhatti, Haq Nawaz,Iqbal, Muhammad Adnan,Khalid, Zohra,Nazari V, Mansoureh,Sarfraz, Ayesha
, (2021/06/03)
Ionic liquids (ILs) are remarkable for biological activities in numerous medical fields. With the aim of enhancing biological potential of azolium based ILs, four new selenium-N-Heterocyclic Carbene (Se-NHC) adducts were synthesized from bis-imidazolium and bis-benzimidazolium molten salts. Synthesized ILs (L1-L4) and Se-NHC adducts (C1[sbnd]C4) were confirmed through elemental analysis, chromatographic and spectroscopic techniques including UHPLC-PDA, FTIR, 1H NMR & 13C NMR spectroscopy as well as mass spectrometry. The compounds were found stable in solution form for upto 96 h measured spectroscopically and showed partition coefficient with optimum lipophilicity measured through shake flask method. The simulation studies of these compounds for cancerous proteins indicated that there could be good to high anticancer potential due to their high affinity and less binding energies for COX-1, EGF, VEGF-A and HIF cancer protein targets. The In Vitro cytotoxicity study of compounds confirmed that these compounds were found highly active showeing IC50 against HCT-116 (1.074–1.116 μg mL?1), A549 (0.977–1.325 μg mL?1) and MCF-7 (0.869–1.378 μg mL?1) which is almost better than standard drug 5-Flourouracil but slightly lower than cisplatin and oxaliplatin. The interaction study of compounds with albumin proteins (BSA) and hemolysis assay assured their least toxicity.
MICROBICIDE AMMONIUM-IMIDAZOLIUM OLIGOMERS AND THEIR ANTI-FUNGAL COMPOSITIONS
-
Page/Page column 27; 30, (2020/04/25)
The present disclosure relates to compositions comprising an oligomer of Formula (I): having imidazolium and diammonium substituents; and an anti-fungal compound comprising at least one triazole group, e.g. fluconazole, itraconazole, or voriconazole. The compositions as described herein may be used as an anti-fungal composition for therapeutic and non-therapeutic applications.
