Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3- methyl-1-(2-methylpropyl)-

Base Information

Chemical Name:Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3- methyl-1-(2-methylpropyl)-
CAS No.:873327-69-6
Molecular Formula:C₂₂H₂₅F₃N₂O₄S₂
Molecular Weight:502.579
Hs Code.:

Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione,
5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-
methyl-1-(2-methylpropyl)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3- methyl-1-(2-methylpropyl)-

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Technology Process of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3- methyl-1-(2-methylpropyl)-

There total 5 articles about Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[(3-hydroxypropyl)thio]-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3- methyl-1-(2-methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873327-68-5
5-(3-hydroxy-propylsulfanyl)-1-isobutyl-3-methyl-6-(2-trifluoromethyl-benzoyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

: 873327-69-6
5-(3-hydroxy-propylsulfanyl)-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.bmcl.2006.01.024

Reference yield:

: 216686-77-0
3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 873327-69-6
5-(3-hydroxy-propylsulfanyl)-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / Br₂ / CH₂Cl₂

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 71 percent / tetrahydrofuran

3.1: 97 percent / tetrapropylammonium perruthenate; NMO / CH₂Cl₂

4.1: K₂CO₃ / dimethylformamide

5.1: NaBH₄ / methanol

With sodium tetrahydroborate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; bromine; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.01.024

Reference yield:

: 259862-18-5
6-bromo-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 873327-69-6
5-(3-hydroxy-propylsulfanyl)-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 71 percent / tetrahydrofuran

2.1: 97 percent / tetrapropylammonium perruthenate; NMO / CH₂Cl₂

3.1: K₂CO₃ / dimethylformamide

4.1: NaBH₄ / methanol

With sodium tetrahydroborate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.01.024