2,6-dichloro-4-(o-tolyl)nicotinonitrile

Base Information

• Chemical Name: 2,6-dichloro-4-(o-tolyl)nicotinonitrile
• CAS No.: 873443-66-4
• Molecular Formula: C13H8Cl2N2
• Molecular Weight: 263.126
• Mol file: 873443-66-4.mol

Synonyms:3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine;3-PYRIDINECARBONITRILE,2,6-DICHLORO-4-(2-METHYLPHENYL);

Chemical Property of 2,6-dichloro-4-(o-tolyl)nicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 4.23548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-4-(o-tolyl)nicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dichloro-4-(o-tolyl)nicotinonitrile

There total 4 articles about 2,6-dichloro-4-(o-tolyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

1',2',3',4'-tetrahydro-5'-cyano-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium, zwitter ion (873443-64-2) → 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine (873443-66-4)

Guidance literature:

With trichlorophosphate; at 135 ℃; for 10h; Heating in Parr bottle;

Reference yield:

5'-cyano-1',2',3',4'-tetrahydro-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium inner salt → 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine (873443-66-4)

Guidance literature:

With trichlorophosphate; at 135 ℃; for 10h;

DOI:10.1021/op060128m

Reference yield:

methyl 2-cyano-3-(2-methylphenyl)-2-propenoate (70625-63-7) → 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine (873443-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 66.02 h / 25 °C / Reflux

2: trichlorophosphate / 10 h / 135 °C

With triethylamine; trichlorophosphate; In methanol;

DOI:10.1021/op060128m

upstream raw materials:

1',2',3',4'-tetrahydro-5'-cyano-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium, zwitter ion

2-methylphenyl aldehyde

methyl 2-cyano-3-(2-methylphenyl)-2-propenoate

Downstream raw materials:

2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

4-(2-methylphenyl)-6-(4-morpholinyl)-3-pyridinecarboxamide

4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide