Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

Base Information

Chemical Name:Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate
CAS No.:342417-02-1
Molecular Formula:C19H24N4O2
Molecular Weight:340.425
Hs Code.:
Mol file:342417-02-1.mol

Synonyms:Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate;[6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester

Suppliers and Price of Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 15 raw suppliers

Chemical Property of Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

Chemical Property:

PSA：57.70000
LogP:3.06300

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

There total 18 articles about Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 342417-01-0
4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide

: 124-41-4
sodium methylate

: 342417-02-1
[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: sodium methylate; With N-Bromosuccinimide; In methanol; dichloromethane; at -5 ℃; for 16h;

4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide; In methanol; dichloromethane; at -5 ℃; for 5.3h;

Reference yield:

: 342417-01-0
4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide

: (quant.) [6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-carbamic acid methyl ester

: 342417-02-1
[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium methylate; In methanol; dichloromethane;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 342417-02-1
[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / toluene / 80 °C

2: toluene / 10 °C

3: tetrahydrofuran

4: 100 °C

5: methanesulfonic acid / 100 °C

6: N-Bromosuccinimide / dichloromethane / -5 °C

With N-Bromosuccinimide; thionyl chloride; methanesulfonic acid; In tetrahydrofuran; dichloromethane; toluene; 6: |Hofmann Rearrangement;
DOI:10.1021/op060128m