2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID
• CAS No.: 873544-80-0
• Molecular Formula: C8H7N3O3S
• Molecular Weight: 225.22400
• Mol file: 873544-80-0.mol

Synonyms:2-Amino-4-methoxy-thieno[2,3-d]pyrimidine-6-carboxylic acid;

Chemical Property of 2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID

Chemical Property:

• PSA: 126.57000
• LogP: 1.56150

Purity/Quality:

2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

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Technology Process of 2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID

There total 6 articles about 2-AMINO-4-METHOXYTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylate (873544-79-7) → 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylic acid (873544-80-0)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

DOI:10.1002/jhet.5570420709

Reference yield: 34.0%

methyl [(2-amino-4-chloro-5-formyl-6-pyrimidinyl)thio]ethanoate (873544-78-6) + sodium methylate (124-41-4) → 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylic acid (873544-80-0) + methyl 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylate (873544-79-7)

Guidance literature:

In methanol; for 9h; Heating;

DOI:10.1002/jhet.5570420709

Reference yield:

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (5604-46-6) → 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylic acid (873544-80-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / Et₃N / aq. methanol / 1.5 h / 20 °C

2: 71 percent / Et₃N / methanol / 18 h / Heating

3: 55 percent / methanol / 9 h / Heating

4: 76 percent / aq. NaOH / methanol / 2 h / Heating

With sodium hydroxide; triethylamine; In methanol;

DOI:10.1002/jhet.5570420709

upstream raw materials:

methyl 2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylate

methyl [(2-amino-4-chloro-5-formyl-6-pyrimidinyl)thio]ethanoate

sodium methylate

2-amino-6-chloro-4-methoxypyrimidine-5-carbaldehyde

Downstream raw materials:

2-amino-4-methoxy-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methoxy-phenyl)-amide

2-amino-4-methoxy-thieno[2,3-d]pyrimidine-6-carboxylic acid (3,4,5-trimethoxy-phenyl)-amide

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