D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester
CAS No.:873552-45-5
Molecular Formula:C30H38N2O5
Molecular Weight:506.642
Hs Code.:

Synonyms:

Suppliers and Price of D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester

There total 3 articles about D-Alanine, N-[[(1R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]carbonyl] -N-methyl-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-05-8,159139-79-4
meta-aminobenzoic acid

: 873552-45-5
Boc-[L-γ-Ach-D-^MeN-Ala]-OFm

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / aq. NaOH; H₂ / Raney Ni / 1 h / 150 °C / 68400 - 76000 Torr

2: aq. DIEA / dioxane / 3 h / 20 °C

3: 231 mg / HATU; DIEA / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; nickel; In 1,4-dioxane; dichloromethane;
DOI:10.1002/chem.200500478

Reference yield:

: 222530-39-4,218772-92-0,222530-33-8
(1R,3S)-3-(tert-butoxycarbonylamino)aminocyclohexanecarboxylic acid

: TFA*H-^MeN-Ala-OFm

: 873552-45-5
Boc-[L-γ-Ach-D-^MeN-Ala]-OFm

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1002/chem.200500478

Reference yield:

: 16636-51-4,25912-50-9,34583-99-8,38541-66-1,57043-02-4,81131-39-7,81131-40-0,41235-88-5,933445-51-3,933445-54-6
(+/-)-cis-3-aminocyclohexanecarboxylic acid

: 873552-45-5
Boc-[L-γ-Ach-D-^MeN-Ala]-OFm

Guidance literature:: Multi-step reaction with 2 steps

1: aq. DIEA / dioxane / 3 h / 20 °C

2: 231 mg / HATU; DIEA / CH₂Cl₂ / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1002/chem.200500478