Neochlorogenin

Base Information

• Chemical Name: Neochlorogenin
• CAS No.: 511-91-1
• Molecular Formula: C₂₇H₄₄O₄
• Molecular Weight: 432.644
• Mol file: 511-91-1.mol

Synonyms:(25R)-5α-spirostane-3β,6α-diol;(25R)-5α-spirostan-3β,6α-diol;Chlorogenin;

Chemical Property of Neochlorogenin

Chemical Property:

• Vapor Pressure: 2.07E-14mmHg at 25°C
• Boiling Point: 550.5°Cat760mmHg
• Flash Point: 286.7°C
• PSA: 58.92000
• Density: 1.16g/cm³
• LogP: 4.76460

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Neochlorogenin

There total 23 articles about Neochlorogenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diosgenin (512-04-9) → chlorogenin (511-91-1,562-33-4,562-34-5,32562-83-7,41743-71-9,72203-51-1,74609-42-0)

Guidance literature:

diosgenin; With diborane; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.75h;

With dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 41.0%

diosgenin (512-04-9) → chlorogenin (511-91-1,562-33-4,562-34-5,32562-83-7,41743-71-9,72203-51-1,74609-42-0) + (3β,5α,6β,25R)-spirostan-3,6-diol (41743-71-9) + (5R)-5-hydroxydiosgenin (85707-31-9)

Guidance literature:

diosgenin; With sodium tetrahydroborate; In tetrahydrofuran; at -20 ℃; for 2h; Inert atmosphere; Sealed tube;

With boron trifluoride diethyl etherate; In tetrahydrofuran;

With methanol; dihydrogen peroxide; potassium hydroxide; In dichloromethane; at 20 ℃; for 1h; Temperature;

DOI:10.1039/d0sc01701a

Reference yield:

(25R)-6α-hydroxy-5α-spirostan-3β-yl O-β-D-xylopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranoside → chlorogenin (511-91-1,562-33-4,562-34-5,32562-83-7,41743-71-9,72203-51-1,74609-42-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 98 ℃; for 2h;

DOI:10.1021/np000230r

upstream raw materials:

aluminum isopropoxide

isopropyl alcohol

(25R)-5α-spirostan-3,6-dione

(25R)-6α-hydroxy-5α-spirostan-3-one

Downstream raw materials:

Di-O-benzoyl-chlorogenin

(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^2,9.0^4,8.0^13,18]icosa-16,18-diene-6,2'-oxane]

chlorogenin

(25R)-3β-hydroxy-5α-spirostan-6-one

Refernces

• 1、 -. "Novel steroid -based amphiphiles and uses thereof". Paragraph 0199-0202. . Retrieved 2020/05/23.
• 2、 Jiang, Biao,Shi, He-ping,Tian, Wei-sheng,Zhou, Wei-shan. "The convergent synthesis of novel cytotoxic certonardosterol D2 from diosgenin". . p. 469 - 476. Retrieved 2008/03/28.