Chemical Property of Omecamtiv mecarbil
Chemical Property:
- Melting Point:180℃
- Boiling Point:456.78 °C at 760 mmHg
- Flash Point:230.052 °C
- PSA：90.29000
- Density:1.344 g/cm3
- LogP:3.01950
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Water Solubility.:40.25mg/L at 25℃
- XLogP3:1.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:401.18631781
- Heavy Atom Count:29
- Complexity:558
- Purity/Quality:
-
99%, *data from raw suppliers
CK1827452 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
- Recent ClinicalTrials:Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure
- Recent EU Clinical Trials:Omecamtiv Mecarbil Post-trial Access Protocol for Subjects Completing Study 20110203 GALACTIC-HF
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Description
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
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Uses
CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452
increases cardiac function by increasing the duration of ejection without changing the rates of contraction. CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
