Piperidine, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl) sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)-

Base Information

Chemical Name:Piperidine, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl) sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)-
CAS No.:873946-53-3
Molecular Formula:C44H52FN7O7S
Molecular Weight:842.004
Hs Code.:

Piperidine,
3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4-
[4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl)
sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)-

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Chemical Property of Piperidine, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl) sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)-

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Technology Process of Piperidine, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl) sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)-

There total 17 articles about Piperidine, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-1-[(4-methylphenyl) sulfonyl]-5-[2-(1H-tetrazol-5-yl)ethoxy]-, (3R,4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873946-54-4
3-[4-{4-[1-(3-fluoro-phenyl)pyrrolidin-3-yloxy]-phenyl}-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxy]-propionitrile

: 873946-53-3
6-{4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-5-[2-(1H-tetrazol-5-yl)-ethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl}-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 100 ℃; for 19h;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 873946-53-3
6-{4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-5-[2-(1H-tetrazol-5-yl)-ethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl}-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

2: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 - 20 h / 15 - 20 °C

5: sodium carbonate / water; ethyl acetate / 1 h / 0 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 72 h / 20 - 50 °C

7: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 19 h / 100 °C

With borane-THF; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; di(n-butyl)tin oxide; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 873946-53-3
6-{4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-5-[2-(1H-tetrazol-5-yl)-ethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl}-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / pyridine; dichloromethane / 1 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 - 20 h / 15 - 20 °C

6: sodium carbonate / water; ethyl acetate / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 72 h / 20 - 50 °C

8: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 19 h / 100 °C

With thionyl chloride; borane-THF; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; di(n-butyl)tin oxide; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;