1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-

Base Information

Chemical Name:1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-
CAS No.:874110-84-6
Molecular Formula:C15H9Cl3N2O
Molecular Weight:339.608
Hs Code.:
DSSTox Substance ID:DTXSID20487379

Synonyms:1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-;874110-84-6;SCHEMBL21121979;DTXSID20487379

Suppliers and Price of 1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-

Chemical Property:

PSA：34.89000
LogP:4.77040
XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:337.978046
Heavy Atom Count:21
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)Cl

Technology Process of 1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]-

There total 3 articles about 1H-Indazole-3-carbonyl chloride, 1-[(2,4-dichlorophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50264-69-2
lonidamine

: 874110-84-6
1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Reflux;
DOI:10.1039/c2dt31936e

Reference yield:

: 4498-67-3
1H-Indazole-3-carboxylic acid

: 874110-84-6
1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

1.3: 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In dichloromethane; mineral oil;
DOI:10.1016/j.bmcl.2016.12.062

Reference yield:

: 94-99-5
2,4-Dichlorobenzyl chloride

: 874110-84-6
1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 3 h / 100 °C / Enzymatic reaction

2: thionyl chloride / 3 h / Reflux

With thionyl chloride; sodium hydroxide; In water;
DOI:10.1002/aoc.5589