EVOMONOSIDE

Base Information

• Chemical Name: EVOMONOSIDE
• CAS No.: 508-93-0
• Molecular Formula: C29H44 O8
• Molecular Weight: 520.664
• Mol file: 508-93-0.mol

Synonyms:Evomonoside(6CI,7CI,8CI); Digitoxigenin 3-rhamnoside; Digitoxigenin rhamnoside; Digitoxigenin-3b-O-a-L-rhamnopyranoside

Chemical Property of EVOMONOSIDE

Chemical Property:

• Boiling Point: 694.6°Cat760mmHg
• Flash Point: 225.4°C
• PSA: 125.68000
• Density: 1.31g/cm³
• LogP: 2.45610

Purity/Quality:

98%min ^*data from raw suppliers

Evomonoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Evomonoside, a Digitoxigenin analogue was isolated from seeds of L. apetalum, and showed antitumor activity.

Technology Process of EVOMONOSIDE

There total 22 articles about EVOMONOSIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C29H42O6 (33156-32-0) → digitoxigenin 3-(α-L-rhamnopyranoside) (508-93-0)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 0 ℃; for 4h;

DOI:10.1021/ml100219d

Reference yield: 76.0%

(3β,5β,14β,17β)-3β-<(2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)oxy>-14-hydroxycard-20(22)-enolide (103368-07-6,103368-08-7) → digitoxigenin 3-(α-L-rhamnopyranoside) (508-93-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 1h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00160a025

Reference yield: 75.0%

evomonoside α-L-rhamnopyranoside tribenzoate (144879-84-5) → digitoxigenin 3-(α-L-rhamnopyranoside) (508-93-0)

Guidance literature:

With ammonium hydroxide; In methanol; for 16h; Ambient temperature;

DOI:10.1021/jm00053a006

upstream raw materials:

(3β,5β,14β,17β)-3β-<(2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)oxy>-14-hydroxycard-20(22)-enolide

evomonoside α-L-rhamnopyranoside tribenzoate

2,3,4-tri-O-acetyl-L-rhamnopyranosyl bromide

(+)-digitoxigenin

Refernces

• 1、 Hauenstein et al.. "-". . p. 87. Retrieved 1953.
• 2、 -. "GLYCOSYLATED CARDIOTONIC STEROIDS". . . Retrieved 2014/12/12.
• 3、 Wang, Hua-Yu Leo,Wu, Bulan,Zhang, Qi,Kang, Sang-Woo,Rojanasakul, Yon,O'Doherty, George A.. "C5′-alkyl substitution effects on digitoxigenin α-l-glycoside cancer cytotoxicity". . p. 259 - 263. Retrieved 2011/06/16.