Glycine, N-[4-(trifluoromethyl)benzoyl]-, ethyl ester

Base Information

• Chemical Name: Glycine, N-[4-(trifluoromethyl)benzoyl]-, ethyl ester
• CAS No.: 87427-94-9
• Molecular Formula: C₁₂H₁₂F₃NO₃
• Molecular Weight: 275.227

Synonyms:

Chemical Property of Glycine, N-[4-(trifluoromethyl)benzoyl]-, ethyl ester

Chemical Property:

• PSA: 55.40000
• LogP: 2.38920

Purity/Quality:

99% ^*data from raw suppliers

(4-Trifluoromethyl-benzoylamino)-aceticacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Glycine, N-[4-(trifluoromethyl)benzoyl]-, ethyl ester

There total 2 articles about Glycine, N-[4-(trifluoromethyl)benzoyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → (4-Trifluoromethyl-benzoylamino)-acetic acid ethyl ester (87427-94-9)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃; for 4h;

DOI:10.1021/jm061132r

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) + glycine ethyl ester hydrochloride (623-33-6) → (4-Trifluoromethyl-benzoylamino)-acetic acid ethyl ester (87427-94-9)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1) DMF, 0 deg C -> room temperature, 20 min, 2) DMF, room temperature, 30 min;

DOI:10.1080/00397919808006857

upstream raw materials:

4-trifluoromethylbenzoic acid

glycine ethyl ester hydrochloride

4-trifluoromethyl-phenyl acetyl chloride

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