Chemical Property of 4-(Trifluoromethyl)benzoic acid
Chemical Property:
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:7.81mmHg at 25°C
- Melting Point:219-220 °C(lit.)
- Refractive Index:1.449
- Boiling Point:243.2 °C at 760 mmHg
- PKA:3.69±0.10(Predicted)
- Flash Point:100.9 °C
- PSA：37.30000
- Density:1.403 g/cm3
- LogP:2.40360
- Storage Temp.:Store below +30°C.
- Water Solubility.:Soluble in water.
- XLogP3:3.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:1
- Exact Mass:190.02416388
- Heavy Atom Count:13
- Complexity:192
- Purity/Quality:
-
99% *data from raw suppliers
4-(Trifluoromethyl)benzoic acid
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36/37-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1C(=O)O)C(F)(F)F
-
Uses
4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N'-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents. 4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via?N,N?-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.
