Cyclopentanol, 3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl-

Base Information

• Chemical Name: Cyclopentanol, 3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl-
• CAS No.: 874375-73-2
• Molecular Formula: C21H20F6O2
• Molecular Weight: 418.379
• Mol file: 874375-73-2.mol

Synonyms:

Chemical Property of Cyclopentanol, 3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanol, 3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl-

There total 5 articles about Cyclopentanol, 3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(((1-phenylcyclopent-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene (874375-72-1) → 3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentanol (874375-73-2)

Guidance literature:

1-(((1-phenylcyclopent-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2013.02.010

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → 3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentanol (874375-73-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 0.5 h / 20 °C

2.1: Grubbs catalyst first generation / dichloromethane / 1 h / Reflux

3.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

5.2: 0 - 20 °C

With Grubbs catalyst first generation; lithium aluminium tetrahydride; borane-THF; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: |Grubbs Olefin Metathesis;

DOI:10.1016/j.bmc.2013.02.010

Reference yield:

(1-phenylcyclopent-3-enyl)methanol (874375-71-0) → 3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentanol (874375-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

2.2: 0 - 20 °C

With borane-THF; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2013.02.010

upstream raw materials:

1-(((1-phenylcyclopent-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

benzeneacetic acid methyl ester

methyl 2-phenyl-2-(prop-2-enyl)pent-4-enoate

methyl 1-phenylcyclopent-3-ene-1-carboxylate

Downstream raw materials:

3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentanone

5-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-5-phenylpiperidin-2-one

4-((3,5-bis(trifluoro-methyl)benzyloxy)methyl)-4-phenylpiperidin-2-one

2-((1S,3R)-3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentyl)isoindoline-1,3-dione