Technology Process of Cyclopentanone,
3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl-
There total 6 articles about Cyclopentanone,
3-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-3-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 1.5h;
Molecular sieve;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 0.5 h / 20 °C
2.1: Grubbs catalyst first generation / dichloromethane / 1 h / Reflux
3.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C
5.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
5.2: 0 - 20 °C
6.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
With
Grubbs catalyst first generation; lithium aluminium tetrahydride; borane-THF; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
2.1: |Grubbs Olefin Metathesis;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C
3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
3.2: 0 - 20 °C
4.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
With
lithium aluminium tetrahydride; borane-THF; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2013.02.010
